医药导报2017，Vol.36Issue(7)：761-766,6.DOI:10.3870/j.issn.1004-0781.2017.07.010
口服银杏叶提取物制剂治疗轻度认知功能障碍Meta分析
Meta-Analysis of Oral Preparation of Ginkgo Biloba Extract in The Treatment of Mid Cognitive Impairment
摘要
Abstract
Objective To evaluate the efficacy and safety of oral ginkgo biloba extract EGB761 in patients with mild cognitive impairment.Methods They searched PubMed,Embase,the Cochrane Library ,CNKI,Wanfang and VIP databases for randomly controlled trials of oral ginkgo biloba extract for mild cognitive impairment.After assessed the quality of studies included,RevMan5.2 software was used to analyze data.Results Seven studies which including 815 patients were involved by our inclusion criteria.The results of meta-analysis showed,compared with the control group,ginkgo biloba was superior in improving mild cognitive impairment patients' MMSE level[MD=1.81,95%CI(0.02,3.60),P=0.05;MD=1.96,95%CI(1.48,2.43),P<0.000 01;MD=1.79,95%CI(0.99,2.58),P<0.000 1] after treated three months、six months and twelve months.Ginkgo biloba was also superior in improving mild cognitive impaimant patients.CDT level[MD=0.43,95%CI(0.30,0.57),P<0.000 01;MD=0.57,95%CI(0.39,0.75),P<0.000 01] after treated six months and twelve months.The effect of preventing MCI patients into dementia was better than that of the control group[RR=0.27,95%CI(0.06,1.27),P=0.10;RR=0.32,95%CI(0.16,0.63),P=0.001]after treated six months and twelve months.Conclusion Oral preparation of ginkgo biloba extract in the treatment of MCI clinical efficacy and prevention of dementia occurrence rate was better than that of blank control group.关键词
银杏叶提取物/银杏叶片/认知功能障碍,轻度/Meta分析Key words
Ginkgo biloba extract/Ginkgo leaf Tablets/Cognitive impairment,mild/Meta-analysis分类
医药卫生引用本文复制引用
曾佩佩,黎红丹,刘泰..口服银杏叶提取物制剂治疗轻度认知功能障碍Meta分析[J].医药导报,2017,36(7):761-766,6.基金项目
广西卫计委资助项目(S201410-01) （S201410-01）
