应用化学2017，Vol.34Issue(6)：611-622,12.DOI:10.11944/j.issn.1000-0518.2017.06.160356
苝酰亚胺衍生物在肿瘤治疗中的应用进展
Application and Progress of Perylenediimides Derivatives in Treating Tumor
摘要
Abstract
At present, malignant tumor has been becoming the main threat to human's death.Chemotherapy is one of the main methods of tumor therapy.However, there are many defects, such as side effects, drug resistance and difficulty of monitoring.Most of research works focus on improving the drugs' therapeutic effect and cutting down it's side effects, drugs' carriers are used to increase its concentration in the local lesions, which promote the efficiency of inhibiting tumor cells and reduce side effects with antitumor drugs.Perylenediimides derivatives(PDI) is a highly stable fluorescing materials, which is easily modified to enhance its biocompatibility and exercise a variety of functions.It can be used as drug carriers, fluorescence imaging, and anticancer drugs for cancers' diagnosis and treatment.This review focuses on the recent progress of PDI's biomedical applications and elaborates from drug carrier, antitumor drugs and fluorescent tracer aspects.This review summarized the basic experimental theory and gave the way for the application of PDI in clinical work.关键词
肿瘤/苝酰亚胺衍生物/药物载体/荧光成像Key words
tumor/perylenediimides/nanocarriers/fluorescence image分类
化学化工引用本文复制引用
李想,金莹莹,刘一博,赵振,李晓,程方,刘中华,黄永伟..苝酰亚胺衍生物在肿瘤治疗中的应用进展[J].应用化学,2017,34(6):611-622,12.基金项目
国家自然科学基金(21572045)、河南省科技发展计划项目(162102310074)、中国博士后科学基金(2013M530335)、中国博士后科学基金(2015T80767)、河南省高校科技创新人才项目(16HASTIT008)、河南大学科研基金项目(xxjc20140019)资助 （21572045）
Supported by the National Natural Science Foundation of China(No.21572045), Project of Science and Technology Department of Henan Province(No.162102310074), China Postdoctoral Science Foundation(No.2013M530335, No.2015T80767), Program for Science & Technology Innovation Talents in the Universities of Henan Province(No.16HASTIT008), Scientific Research Fund project of Henan University(No.xxjc20140019) （No.21572045）
