应用化学2017，Vol.34Issue(6)：685-692,8.DOI:10.11944/j.issn.1000-0518.2017.06.160393
呸啶衍生物的合成及抑菌性
Synthesis and Biological Activity of Perimidine Derivatives
摘要
Abstract
Perimidine is a multi-nuclear N-heterocyclic compound, which plays an important role in industrial and biological fields.Perimidines have been drawn extensive examinations from many researchers for a long time due to the nitrogen heterocyclic ring.Here, a series of perimidine derivatives(4a~4g and 6) was synthesized through 1,8-diaminonaphthalene and aldehydes.The products were characterized by infrared spectroscopy(IR), proton or carbon nuclear magnetic resonance(1H NMR, 13C NMR), high resolution mass spectrometry(HRMS).Compounds 4a and 6 were investigated by single-crystal X-ray diffraction.X-ray analysis reveals that both of crystals of 4a and 6 are made up of monoclinic unit cells with space group P21/n.In addition, the biological activity assay was carried out.The results show that perimidine derivatives have a diverse range of biological activities against the fungi, which indicates that perimidine derivatives have great potential applications in antibacterial fields in the future.And test data indicate that there is no obvious regulation between fungicidal activity and the different substituents on the benzene ring.关键词
呸啶/合成/晶体结构/抑菌活性Key words
perimidine/synthesis/crystal structure/biological activity分类
化学化工引用本文复制引用
袁霖,李中燕,贾国凯,张敏,袁先友..呸啶衍生物的合成及抑菌性[J].应用化学,2017,34(6):685-692,8.基金项目
Supported by the Natural Science Foundation of Hu'nan Province of China(No.2017JJ3093), the Scientific Research Fund of Hu'nan Provincial Education Department(No.16B104), the Opening Project of Key Laboratory of Comprehensive Utilization of Advantage Plants Resources in Hu'nan South(No.XNZW16C01), the Scientific Research Fund of Hu'nan University of Science and Engineering(No.16XKY063) （No.2017JJ3093）
湖南省自然科学基金(2017JJ3093)、湖南省教育厅科学研究(16B104)、湘南优势植物资源综合利用湖南省重点实验室资助(XNZW16C01)和湖南科技学院科学研究(16XKY063)资助项目 （2017JJ3093）
