湖北医药学院学报2017，Vol.36Issue(2)：112-115,119,封2,6.DOI:10.13819/j.issn.1006-9674.2017.02.004
急性给予喹吡罗抑制C57BL/6J小鼠的感觉运动门控功能
Acute Quinpirole Treatment Inhibits Sensory Motor Gating of C57BL/6J Mice
摘要
Abstract
Objective To investigate the effects of quinpirole after acute treatment on acoustic startle reflex (ASR) and sensory motor gating in C57BL/6J mice.Methods 24 mice were randomly divided into three groups,the control group (n =8),the low-dosage group (n=8),and the high-dosage group (n=8).The mice in the low-dosage group and high-dosage group were given quinpirole 1 mg/kg and 3mg/kg injection,respectively.The control group was treated with equal volume of saline.All mice received ASR and pre-pulse inhibit (PPI) tests by Startle reflex system before and after drug administration.Results The PPI rate was about 50％ after the mouse was measured ASR and PPI test.The maximum startle magnitude (0.0707±0.0013) N and PPI rate (42.73 ± 7.13)％ were significantly lower than those before saline injection [(0.0813±0.0047) N,(39.53±4.02) ％] (P＜0.05).The maximum startle magnitude (0.0654±0.0093) N in the low dose experimental group was lower than that in the control group (0.0813±0.0047) N and the control group (0.0823±0.0074)N (P＜0.05),and its ％PPI (32.66±6.24)％ were lower than those in the control group (49.58±5.03)％,but there was no significant difference between each group (P ＞ 0.05).The maximum startle magnitude (0.0307 ± 0.0026)N and ％ PPI (14.48±6.14)％ which in the high dose group were significantly lower than those in the baseline group (0.0864±0.0143) N and (45.24± 10.11) ％,compared with the control group (P＜0.05).Conclusion Acute injection with high doses of quinpirole reduced the prepulse inhibition of auditory startle reflex,and injured the sensory motor gating function in C57BL/6J mice,probably via dysregulation of PPI in the limbic system.关键词
感觉运动门控/惊跳反射/弱刺激抑制/喹吡罗/行为学Key words
Quinpirole/sensory motor gating/Startleacoustic startle reflex/Prepulse inhibition/Quinpirole, Behavior引用本文复制引用
邹利,彭小倩,王云甫..急性给予喹吡罗抑制C57BL/6J小鼠的感觉运动门控功能[J].湖北医药学院学报,2017,36(2):112-115,119,封2,6.基金项目
国家自然科学基金(81671238) （81671238）
湖北省公益性科技研究项目(2012DCA12006) （2012DCA12006）
湖北医药学院优秀中青年科技创新团队资助计划项目(2014CXX01) （2014CXX01）
