诊断学理论与实践2017，Vol.16Issue(3)：320-323,4.DOI:10.16150/j.1671-2870.2017.03.017
妊娠早期联合母血清妊娠相关蛋白A与子宫动脉超声多普勒预测胎儿生长受限的价值探讨
Prediction of fetal growth restriction by uterine artery Doppler and level of PAPP-A at 11-13+6 weeks of gestation
摘要
Abstract
Objective: To evaluate the predictive level for fetal growth restriction (FGR) at 11-13 +6 weeks of gestation by uterine artery Doppler or/and level of PAPP-A. Methods: A prospective study was performed on 2000 singleton preg-nancies attending routine care at 11-13+6 weeks of gestation. Uterine artery Doppler ultrasound was performed and mater-nal serum pregnancy associated plasma protein A( PAPP-A) level was assayed. The maternal and neonatal outcome were followed up. Results: ① Among the 2000 cases,13 pregnancies were terminated for fetal abnormalities or intrauterine fe-tal death before 28 weeks, 76 cases developed FGR, 426 cases were proved having other adverse pregnancy outcomes, and the remaining 1485 cases had normal outcomes. ② Compared with normal group, the mean uterine artery pulsatility index (PI)and uterine resistance index(RI)and the presence of early diastolic notch in blood flow were higher and PAPP-A level was lower in FGR group. ③ In screening FGR, the combination of uterine artery PI and PAPP-A had a sensitivity of 81.6%, and the combination of uterine artery PI, PAPP-A and the presence of early diastolic notch increased the sensitivi-ty to 82.9%, yet the difference did not reach statistical significance. Conclusions: Uterine artery PI together with PAPP-A and presence of early diastolic notch at 11-13+6 weeks could provide sensitive prediction of the development of FGR. How-ever, the effectiveness of presence of early diastolic notch is not as good as that of uterine artery PI or maternal serum PAPP-A level in screening FGR.关键词
超声多普勒/胎儿生长受限/子宫动脉/早孕期Key words
Doppler/Fetal growth restriction/Uterine artery/First trimester分类
医药卫生引用本文复制引用
何碧媛,周毓青..妊娠早期联合母血清妊娠相关蛋白A与子宫动脉超声多普勒预测胎儿生长受限的价值探讨[J].诊断学理论与实践,2017,16(3):320-323,4.基金项目
长宁区卫计委重点专科项目(20161005) （20161005）
长宁区卫计委委级课题(20154Y013) （20154Y013）
