摘要
Abstract
Objective: To investigate the expression and significance of metastasis associated gene 1(MTA1) protein in normal cervix, chronic cervicitis, cervical intraepithelial neoplasia (CIN) and cervical cancer tissues. Methods: Biopsy paraffin sections including 40 cases of cervical cancer,45 cases of CIN, 30 cases of chronic cervicitis, 20 cases of normal cervix were investigated. Expression of MTA1 protein were examined by immunohistochemistry, and results were analyzed statistically using semiquantitative method. The correlation of MTA1 expression with biological behavior of cervical cancer was explored, including pathological classification, histological grade, clinical stage and lymph node metastasis. Results:Rates of high expression of MTA1 differed between cervical cancer, CIN and normal cervix (P<0.05). There was no differ-ence in rate of high expression of MTA1 between chronic cervicitis and normal cervix (P>0.05). There were significant di-fferences in high expression rate of MTA1 between low grade squamous intraepithelial lesion(LSIL), high grade squamous intraepithelial lesion (HSIL) and cervical cancer tissues ( P<0.05). Rate of high expression of MTA1 was correlated with degree of differentiation, lymph node metastasis and clinical stage, and was not associated with pathological type. Conclusions: MTA1 expression is low in normal and chronic cervicitis issue, and is high in CIN and cervical cancer tis-sue. Rate of high expression of MTA1 is in close association with the differentiation degree, lymph node metastasis and clinical stage of cervical cancer.关键词
宫颈癌/宫颈上皮内瘤变/转移相关基因1/免疫组织化学Key words
Cervical cancer/Cervical intraepithelial neoplasias/Metastasis associated gene 1/Immunohistochemical methods分类
医药卫生
