中国当代儿科杂志2017，Vol.19Issue(7)：754-758,5.DOI:10.7499/j.issn.1008-8830.2017.07.005
中国新生儿先天性心脏病危险因素的Meta分析
Risk factors for congenital heart disease in Chinese neonates: a Meta analysis
摘要
Abstract
Objective To investigate the major risk factors for congenital heart disease (CHD) in Chinese neonates and to provide a reference for the prevention of CHD. Methods A literature search was performed to collect the case-control studies on the risk factors for CHD in Chinese neonates published in 2001-2016. The relevant data were extracted accordingly. The quality of included studies was assessed by Newcastle-Ottawa Scale. Sensitivity analysis was conducted using different models to analyze the same data. The publication bias was assessed by Egger's test. Results A total of 17 case-control studies involving 2930 cases and 4952 controls were included. The Meta analysis showed that the major risk factors for CHD in Chinese neonates were as follows: mother with advanced age (OR=2.649, 95%CI:1.675-4.189), cold or fever (OR=4.558, 95%CI: 2.901-7.162), medication use in early pregnancy (OR=3.961, 95%CI:2.816-5.573), passive smoking (OR=2.766, 95%CI: 1.982-3.859), abnormal childbearing history (OR=2.992, 95%CI:1.529-5.856), noise exposure (OR=3.030, 95%CI: 1.476-6.217), radiation exposure (OR=2.363, 95%CI: 1.212-4.607), decoration (OR=4.979, 95%CI: 3.240-7.653), gestational diabetes (OR=5.090, 95%CI: 3.132-8.274), and pet raising (OR=2.048, 95%CI: 1.385-3.029). Conclusions Mothers with advanced age, cold or fever, medication use in early pregnancy, passive smoking, abnormal childbearing history, noise exposure, radiation exposure, decoration, gestational diabetes, and pet raising may increase the risk of CHD in Chinese neonates.关键词
先天性心脏病/危险因素/Meta分析/新生儿Key words
Congenital heart disease/Risk factor/Meta analysis/Neonate引用本文复制引用
刘毅,张文辉,朱蓓,卓琳,何明喻,许阳,王彤彤,蔡卿卿,胡斌,徐继承..中国新生儿先天性心脏病危险因素的Meta分析[J].中国当代儿科杂志,2017,19(7):754-758,5.基金项目
江苏高校哲学社会科学研究一般项目(2015SJB414). （2015SJB414）
