中国当代儿科杂志2017，Vol.19Issue(7)：786-789,4.DOI:10.7499/j.issn.1008-8830.2017.07.011
可乐定透皮贴片治疗儿童中重度抽动障碍的临床研究
Efficacy of clonidine transdermal patch in treatment of moderate to severe tic disorders in children
郭敬民 1施晓茜 1杨式薇 1钱沁芳 1黄艳 1谢燕钦 1欧萍1
作者信息
- 1. 福建医科大学附属福建省妇幼保健院,福建 福州 350001
- 折叠
摘要
Abstract
Objective To investigate the difference in the efficacy between clonidine transdermal patch and haloperidol tablets in the treatment of moderate to severe tic disorders in children. Methods A total of 134 children with moderate to severe tic disorders were randomly divided into clonidine group (n=70) and haloperidol group (n=64). The clonidine and haloperidol groups were treated with clonidine transdermal patch and haloperidol tablets respectively, and the treatment lasted for 8 weeks in both groups. The Yale Global Tic Severity Scale (YGTSS) was used to evaluate the conditions of the children before and after treatment, and the adverse events during the treatment were recorded. Results The haloperidol group had a significantly better treatment outcome than the clonidine group after one week of treatment (P<0.05); the treatment outcome showed no significant difference between the two groups after 3, 5, and 8 weeks of treatment (P>0.05). The clonidine group had significantly less reductions in the motor tics, vocal tics, and function impairment scores and total score of YGTSS than the haloperidol group after one week of treatment (P<0.05); there were no significant differences in YGTSS score reductions between the two groups after 3, 5, and 8 weeks of treatment (P>0.05). The clonidine group had a significantly lower overall incidence of adverse events than the haloperidol group (8% vs 37%; P<0.01). Conclusions Clonidine transdermal patch and haloperidol are both effective in the treatment of moderate to severe tic disorders in children. The clonidine transdermal patch, despite slow action, has comparable efficacy and fewer adverse effects compared with haloperidol.关键词
可乐定透皮贴片/抽动障碍/疗效/儿童Key words
Clonidine transdermal patch/Tic disorder/Efficacy/Child引用本文复制引用
郭敬民,施晓茜,杨式薇,钱沁芳,黄艳,谢燕钦,欧萍..可乐定透皮贴片治疗儿童中重度抽动障碍的临床研究[J].中国当代儿科杂志,2017,19(7):786-789,4.
