中国当代儿科杂志2017，Vol.19Issue(7)：806-811,6.DOI:10.7499/j.issn.1008-8830.2017.07.015
IL-6 C-572G多态性位点与自发性早产遗传易感性的关系
Association between IL-6 C-572G and susceptibility to spontaneous preterm birth
摘要
Abstract
Objective To investigate the association between the genetic polymorphism of IL-6 C-572G and susceptibility to spontaneous preterm birth (SPTB). Methods The subjects were from Beijing and the surrounding areas of Beijing. This case-control study enrolled 569 SPTB infants, including 56 extremely preterm (<28 weeks of gestation), 166 very preterm (28-31+6 weeks of gestation) and 347 moderate to late preterm infants (32 to 36+6 weeks of gestation). A total of 673 term infants were enrolled as the control group. The latest Sequenom MassARRAY?SNP detection technique was used for the typing of single nucleotide polymorphism of IL-6 C-572G. Results Compared with the CC genotypes, the IL-6 C-572G G-positive genotype (CG+GG genotype) was significantly associated with an increased susceptibility to moderate to late SPTB (OR=1.35, 95%CI: 1.01-1.80, P=0.04). Conclusions Among the Chinese population, IL-6 C-572G polymorphism is associated with susceptibility to moderate to late SPTB.关键词
白细胞介素6/自发性早产/单核苷酸多态性/易感性/早产儿Key words
Interleukin 6/Spontaneous preterm birth/Single nucleotide polymorphism/Susceptibility/Preterm infant引用本文复制引用
杨晓,彭薇,朱丽娜,张小爱,王艳..IL-6 C-572G多态性位点与自发性早产遗传易感性的关系[J].中国当代儿科杂志,2017,19(7):806-811,6.基金项目
国家自然科学基金(81300527). （81300527）
