中国动脉硬化杂志2017，Vol.25Issue(6)：590-593,4.
强化剂量阿托伐他汀对不稳定型心绞痛患者PCI围手术期B7-H3、B7-H4的影响
Effect of intensive dose atorvastatin on B7-H3, B7-H4 in patients with unstable angina pectoris undergoing percutaneous coronary intervention
摘要
Abstract
Aim To investigate the effect of intensive dose atorvastatin therapy on B7-H3,B7-H4 in peripheral blood monocytes of patients with unstable angina pectoris undergoing percutaneous coronary intervention (PCI).Methods The patients with unstable angina pectoris were randomly divided into conventional dose group (atorvastatin 20 mg/d,n=40) and intensive dose group (atorvastatin 80 nag/d,n =40),peripheral blood were collected before and 18 h ～ 24 h after PCI.Enzymelinked immunosorbent assay was used to detect peripheral blood IL-4,IL-10,IFN-γand sB7-H3,sB7-H4,fluorescence-based quantitive real-time PCR was used to measure B7-H3 and B7-H4 mRNA.Results The levels of IL-10,sB7-H3,sB7-H4 and the expression of B7-H3 and B7-H4 mRNA in the two groups after PCI were higher than those before PCI,and the increase of the intensive dose group was more significant than that of the conventional dose group (P＜0.05).On the contrary,the levels of IL-4 and IFN-γin the two groups after PCI were decreased,and the decrease of the intensive dose group was more obvious than that of the conventional dose group (P＜0.05).Conclusion Intensive dose atorvastatin may promote the expression of B7-H3 and B7-H4,thereby reducing the immune inflammation in patients with unstable angina pectoris after PCI.关键词
不稳定型心绞痛/阿托伐他汀/B7-H3/B7-H4Key words
Unstable angina pectoris/Atorvastatin/B7-H3/B7-H4分类
医药卫生引用本文复制引用
吕静,徐戈,黄琛,雷敏,张晶晶,马冰宁..强化剂量阿托伐他汀对不稳定型心绞痛患者PCI围手术期B7-H3、B7-H4的影响[J].中国动脉硬化杂志,2017,25(6):590-593,4.基金项目
广西科学研究与技术开发计划项目(科技攻关1355005-4-6) （科技攻关1355005-4-6）
