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中性粒细胞胞外陷阱网在动脉粥样硬化进展中的作用

左海奇 李碧澄

中国动脉硬化杂志2017,Vol.25Issue(6):635-639,5.
中国动脉硬化杂志2017,Vol.25Issue(6):635-639,5.

中性粒细胞胞外陷阱网在动脉粥样硬化进展中的作用

Neutrophil extracellular traps have a role in the development of atherosclerosis

左海奇 1李碧澄1

作者信息

  • 1. 哈尔滨医科大学附属第一医院心血管内科,黑龙江省哈尔滨市150001
  • 折叠

摘要

Abstract

Atherosclerosis,which takes place in the walls of arteries,is a long-term progressive inflammatory pathological process.The rupture of atherosclerotic plaque and thus thrombosis may lead to acute cardiovascular events which threaten human health and life seriously.Recently,the role of neutrophils in atherosclerosis is attractted much attention.Activated neutrophils release web-like structures known as neutrophil extracellular traps (NETs).NETs affect the pathologic process in the patients with autoimmune diseases,acute lung injury,deep vein thrombosis,etc.A large number of studies indicate that NETs is associated with the formation of atherosclerosis and thrombosis.NETs,which act as predictive factors in coronary artery diseases,predict the major adverse cardiac events and the prognosis.This article is aimed to review the role of neutrophil extracellular traps in the development of atherosclerosis.

关键词

中性粒细胞胞外陷阱网/动脉粥样硬化/动脉粥样硬化性血栓

Key words

Neutrophil extracellular traps/Atherosclerosis/Atherothrombosis

分类

医药卫生

引用本文复制引用

左海奇,李碧澄..中性粒细胞胞外陷阱网在动脉粥样硬化进展中的作用[J].中国动脉硬化杂志,2017,25(6):635-639,5.

基金项目

国家自然科学基金项目(81371709) (81371709)

中国动脉硬化杂志

OACSTPCD

1007-3949

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