肝细胞肝癌组织异黏蛋白的表达变化及临床意义OACSTPCD
Expression and clinical significance of metadherin in hepatocellular carcinoma
目的:观察异黏蛋白(metadherin, MTDH)在肝细胞肝癌(HCC)组织中的表达变化,并探讨其可能的临床价值.方法:对含323例肝细胞肝癌患者肿瘤及癌旁正常肝脏组织的组织芯片进行免疫组化染色,分析MTDH的表达情况及其与肝癌患者临床特征之间的关系.进一步采用免疫共沉淀(Co-Immunoprecipitation, Co-IP)结合质谱(mass spectrometry)技术寻找异黏蛋白的功能复合体.结果:免疫组化结果显示MTDH在肝癌…查看全部>>
Objective:To investigate the expression of metadherin (MTDH) in hepatocellular carcinoma (HCC) and its role in promoting HCC metastasis.Methods:The expression of MTDH in HCC and adjucent normal tissues was detected.Co-Immunoprecipitation (Co-IP) and mass spectrometry was used to investigate the protein complex involving MTDH.Results:The expression of MTDH was significantly higher in HCC tumors than that in corresponding normal liver tissues, and tumors with …查看全部>>
朱凯;战昊;周俭;樊嘉;代智
复旦大学附属中山医院肝脏外科,复旦大学肝癌研究所,上海 200032教育部癌变与侵袭原理重点实验室,上海 200032复旦大学附属中山医院肝脏外科,复旦大学肝癌研究所,上海 200032教育部癌变与侵袭原理重点实验室,上海 200032复旦大学附属中山医院肝脏外科,复旦大学肝癌研究所,上海 200032
医药卫生
异黏蛋白肝细胞肝癌肿瘤转移预后
metadherinhepatocellular carcinomaneoplasm metastasisprognosis
《中国临床医学》 2017 (3)
巨噬细胞内HSP27表达调控其亚型转化并影响肝癌侵袭转移的作用机制
334-338,5
国家自然科学基金(81402376,81472218),复旦大学附属中山医院人才培养计划-优秀骨干计划(2015ZSYXGG).Supported by National Natural Science Foundation of China(81402376,81472218)and the Talent Development Program of Zhongshan Hospital, Fudan University (2015ZSYXGG).
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