中国临床医学2017，Vol.24Issue(3)：334-338,5.DOI:10.12025/j.issn.1008-6358.2017.20170364
肝细胞肝癌组织异黏蛋白的表达变化及临床意义
Expression and clinical significance of metadherin in hepatocellular carcinoma
摘要
Abstract
Objective:To investigate the expression of metadherin (MTDH) in hepatocellular carcinoma (HCC) and its role in promoting HCC metastasis.Methods:The expression of MTDH in HCC and adjucent normal tissues was detected.Co-Immunoprecipitation (Co-IP) and mass spectrometry was used to investigate the protein complex involving MTDH.Results:The expression of MTDH was significantly higher in HCC tumors than that in corresponding normal liver tissues, and tumors with microvascular invasion, pathological satellites, poor differentiation, or TNM stage Ⅱ-Ⅲ were prone to exhibit higher MTDH expression (P<0.01).The clinical outcome was poorer in the MTDH high group than that in the MTDH low group in both the 1-, 3-, 5-year overall survival rates (OS) and the 1-, 3-, 5-year cumulative recurrence rates (P<0.05).CO-IP results showed that MTDH can form a complex with PRMT5.Conclusions:MTDH can accurately predict the poor outcome of HCC patients after surgery, and is a great independent prognostic indicator.关键词
异黏蛋白/肝细胞肝癌/肿瘤转移/预后Key words
metadherin/hepatocellular carcinoma/neoplasm metastasis/prognosis分类
医药卫生引用本文复制引用
朱凯,战昊,周俭,樊嘉,代智..肝细胞肝癌组织异黏蛋白的表达变化及临床意义[J].中国临床医学,2017,24(3):334-338,5.基金项目
国家自然科学基金(81402376,81472218),复旦大学附属中山医院人才培养计划-优秀骨干计划(2015ZSYXGG).Supported by National Natural Science Foundation of China(81402376,81472218)and the Talent Development Program of Zhongshan Hospital, Fudan University (2015ZSYXGG). （81402376,81472218）
