中国临床医学2017，Vol.24Issue(3)：339-342,4.DOI:10.12025/j.issn.1008-6358.2017.20170065
促性腺激素释放激素拮抗剂方案与激动剂长方案应用于新鲜胚胎移植患者的疗效比较
Efficacy comparison of GnRH antagonist protocol and GnRH long protocol for the patients undergoing fresh embryo transfer
摘要
Abstract
Objective:To compare the clinical effect between gonadotrophin-releasing hormone (GnRH) antagonist protocol and GnRH agonist long protocol in patients obtaining fresh embryo transfer.Methods:Clinical data of patients in the fresh embryo transfer cycle were analyzed retrospectively.Main clinical outcomes including superovulation and pregnant rates were compared.Results:A total of 706 cases were selected, 637 patients received GnRH agonist long protocol, and 69 patients received antagonist protocol.Compared with agonist group, the patients in antagonist group had significantly shorter duration of gonadotropin ([10.55±1.38] d vs [11.20±1.84] d), fewer doses ([1 699.50±611.25] U vs [2 196.75±765.75] U, P<0.05), more oocytes (12.11±5.20 vs 9.69±3.86, P<0.05), and more MⅡoocytes (10.15±4.65 vs 8.26±3.50, P<0.05).However, there was no significant difference in thickness of endometrium, fertilization rate, implantation rate, and pregnant rate between the two groups.Conclusions:Compared with the long GnRH agonist protocol, the GnRH antagonist protocol can bring out a substantial increase in the number of good quality embryos among the patients receiving fresh embryo transfer, but shows no advantage in pregnant rate.关键词
胚胎移植/妊娠率/GnRH拮抗剂/GnRH激动剂Key words
embryo transfer/pregnant rate/GnRH antagonist/GnRH agonist分类
医药卫生引用本文复制引用
陈军玲,刘素英,李路,陈国武,张璇,孙晓溪..促性腺激素释放激素拮抗剂方案与激动剂长方案应用于新鲜胚胎移植患者的疗效比较[J].中国临床医学,2017,24(3):339-342,4.基金项目
上海市卫生与计划生育委员会课题基金(20134146).Supported by Foundation of Shanghai Municipal Health and Family Planning Commission (20134146). （20134146）
