中国临床医学2017，Vol.24Issue(3)：363-368,6.DOI:10.12025/j.issn.1008-6358.2017.20170150
体素内不相干运动扩散加权成像对肾癌分型的诊断价值
The diagnostic value of IVIM-DWI in subtype differentiation of renal cell carcinoma
摘要
Abstract
Objective:To investigate the value of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) in the classification of renal cell carcinoma (RCC), and to evaluate the correlation between the perfusion-related parameters (D* and f) and the percentage of enhanced lesion and microvascular density (MVD).Methods:The data of 57 pathologically confirmed cases of renal cell carcinoma (RCC) in 52 patients between May 2013 and March 2015 were retrospectively analyzed.All patients underwent conventional MRI and IVIM-DWI scanning.36 cases of RCC in 34 patients underwent immunohistochemistry CD34 staining to evaluate MVD.One-way ANOVA, Pearson correlation analysis and receiver operating characteristic (ROC) curve were used for statistical analysis.Results:The ADC and D values of clear cell renal cell carcinoma (ccRCC) were higher than those of papillary renal cell carcinoma (pRCC) and chromophobe renal cell carcinoma (chRCC, P<0.01), but there was no significant statistical difference between the ADC and D values of pRCC and chRCC (P=0.536).There was no significant statistical difference between the D* values of ccRCC and chRCC.The f values of 3 subtypes of RCC were statistically different (all P<0.05).The areas under the ROC curve (AUC) of ADC, D, D* and f values in the differentiation between ccRCC and non-ccRCC were 0.84, 0.85, 0.65, and 0.80 respectively.The D* and f values were positively correlated with the percentage of enhanced lesions in corticomedullary phase and parenchymal phase (r=0.45, 0.30;0.56, 0.55, respectively).The D* and f values were both positively correlated with the MVD value of renal cell carcinoma (r=0.362 and 0.501 respectively).Conclusions:IVIM-DWI is valuable in helping to differentiate among RCC subtypes.Perfusion-related parameters D* and f have certain correlation with the percentage of lesion enhancement and MVD.关键词
体素内不相干运动/扩散加权成像/肾细胞癌/强化程度/微血管密度Key words
intravoxel incoherent motion/diffusion weighted imaging/renal cell carcinoma/degree of enhancement/microvascular density分类
医药卫生引用本文复制引用
丁玉芹,胡骁轶,戴辰晨,冒炜,曾蒙苏,周建军..体素内不相干运动扩散加权成像对肾癌分型的诊断价值[J].中国临床医学,2017,24(3):363-368,6.基金项目
上海市自然科学基金(14ZR1438400).Supported by Natural Science Foundation of Shanghai(14ZR1438400). （14ZR1438400）
