中国临床医学2017，Vol.24Issue(3)：382-386,5.DOI:10.12025/j.issn.1008-6358.2017.20170194
血清25-羟基维生素D和骨钙素水平对2型糖尿病患者病程转归的预警价值
Warning effects of serum 25-hydroxyvitamin D and osteocalcin levels on the progression of type 2 diabetes mellitus
摘要
Abstract
Objective:To explore the warning effect of serum levels of 25-hydroxy vitamin D (25-OH-VD) and osteocalcin(OC) with the prognosis of type 2 diabetes mellitus (T2DM).Methods:The case group of 116 cases of T2DM were selected from the patients hospitalizedin the department of endocrinology, Jinshan Hospital, Fudan University from Jan.to Dec.in 2013, and 50 cases of health volunteers from the outpatient of physical examination in our hospital were collected as the control group.The age, body mass index(BMI), fasting blood glucose (FBG), blood lipid, blood pressure and 25-OH-VD and OC were compared between the two groups.In the case group, the correlation of 25-OH-VD and OC with nephropathy were analyzed, and then multiple stepwise regression was used to analyze the statistical relationship of 25-OH-VD and OC with blood lipid, blood pressure, BMI, FBG, glycosylated hemoglobin (HbA1c), fast insulin (FINS), homeostasis model assessment for insulin resistance index (HOMA-IR), creatinine (CR), uric acid (UA)and carotid artery intimal medial thickness (CA-IMT).Results:There was no statistical difference in age, blood pressure, BMI and blood lipid between the case group and the control group, while the levels of 25-OH-VD and OC were lower in the case group compared with the control group ([13.91±7.13] ng/mL vs [30.35±19.7] ng/mL, P=0.000;[4.02±1.66] ng/mL vs [6.62±1.68] ng/mL, P=0.000).In the case group, patients with nephropathy had lower 25-OH-VD level than those with normal urine microalbumin (U-MA) ([10.33±3.46] ng/mL vs [16.45±7.95] ng/mL,P=0.000), while there was no statistical difference in OC level ([3.91±1.67] ng/mL vs [4.09±1.67] ng/mL, P=0.558).25-OH-VD level of T2DM patients has no correlation with BMI, blood lipid, blood pressure, FBG, HbA1c, FINS, HOMA-IR, CR, UA and CA-IMT.OC level of T2DM patients has negative correlation with FBG, HbA1c and HOMA-IR, and positive correlation with FINS, CR and CA-IMF, therefore HbA1c and FBG were the independent influence factor of OC.Conclusions:Serum levels of 25-OH-VD and OC can be seen as the warning singles of T2DM progression.25-OH-VD has correlation with diabetic nephropathy, and OC has correlation with diabetic microangiopathy.关键词
2型糖尿病/25-羟基维生素D/骨钙素Key words
type 2 diabetes mellitus/25-hydroxy vitamin D/osteocalcin分类
医药卫生引用本文复制引用
姜文娟,张进安,黎丹凤..血清25-羟基维生素D和骨钙素水平对2型糖尿病患者病程转归的预警价值[J].中国临床医学,2017,24(3):382-386,5.基金项目
上海市金山区卫计委基金(JSKJ-KTQN-2014-06).Supported by Foundation of Health and Family Planning Commission of Jinshan District of Shanghai (JSKJ-KTQN-2014-06). （JSKJ-KTQN-2014-06）
