中国临床医学2017，Vol.24Issue(3)：416-419,4.DOI:10.12025/j.issn.1008-6358.2017.20161006
缺血修饰清蛋白、胱抑素C及氨基末端脑钠肽前体对急性冠状动脉综合征的联合诊断价值
Diagnostic value of IMA, CysC, and NT-proBNP in acute coronary syndrome
乔利阳 1杜长春 2周向东3
作者信息
- 1. 河南省胸科医院心血管外科, 郑州 450000
- 2. 河南省胸科医院急诊科, 郑州 450000
- 3. 河南省胸科医院心内科, 郑州 450000
- 折叠
摘要
Abstract
Objective:To investigate the value of ischemia modified protein (IMA), Cystatin C (CysC) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in early diagnosis of acute coronary syndrome (ACS) and its clinical significance.Methods:120 patients with ACS (the ACS group) treated in the Department of Emergency or Cardiology of Henan Provincial Chest Hospital from June 2015 to June 2016 were selected, and a total of 50 healthy subjects (the healthy group) were also selected.The serum levels of IMA, CysC, and NT-proBNP were compared between the two groups, and the sub-group analysis was performed according to the results of disease diagnosis.The receiver operating characteristic curve (ROC) was used to analyze the diagnostic value of IMA, CysC, and NT-proBNP in early differential diagnosis of ACS.Results:The level of IMA in the ACS group was lower than that in the healthy group (P<0.05).The levels of CysC and NT-proBNP in the ACS group were higher than those in the healthy group (P<0.05).There was no significant difference in the IMA level between ST segment elevation myocardial infarction (STEMI), non ST segment elevation myocardial infarction (NSTEMI) or UA subgroup.The NT-proBNP level in the STEMI group was higher than that in the NSTEMI group (P<0.05).The scores of CysC, NT-proBNP, and Gensini in the STEMI group and the NSTEMI group were higher than those in UA group (P<0.05).The sensitivity of IMA+CysC+NT-proBNP in diagnosing ACS was 86.29%, specificity was 92.23%, and the value of AUC was 0.912.Conclusions:IMA+CysC+NT-proBNP combined diagnosis of ACS has high clinical practical value.关键词
缺血修饰蛋白/胱抑素C/氨基末端脑钠肽前体/急性冠状动脉综合征Key words
ischemia modified protein/cystatin C/N-terminal pro-brain natriuretic peptide/acute coronary syndrome分类
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乔利阳,杜长春,周向东..缺血修饰清蛋白、胱抑素C及氨基末端脑钠肽前体对急性冠状动脉综合征的联合诊断价值[J].中国临床医学,2017,24(3):416-419,4.
