中国临床药学杂志2017，Vol.26Issue(3)：177-180,4.
去甲斑蝥素温敏型原位凝胶的制备及其体外释放特性
Studies on preparation and drug release characteristics of norcantharidin temperature-sensitive in situ gel in vitro
摘要
Abstract
AIM To prepare temperature-sensitive situ gel of norcantharidin and investigate its pharmaceutical properties.METHODS Gel temperature and dissolution time in vitro were used as an index,using uniform design to determine the optimum process,and the release of norcantharidin temperature-sensitive in situ gel in vitro was evaluated by using the equilibrium dialysis method.RESULTS The optimal prescription was established as poloxamer 407 ratio of 28％,poloxamer 188 ratio of 1.6％,and hydroxypropyl methyl cellulose ratio of 0.1％ after a uniform design experiment.The gelation temperature of prepared norcantharidin temperature-sensitive in situ gel was 34℃ and dissolution time in vitro was 210 min.The drug release curve of norcantharidin temperature-sensitive in situ gel in vitro was ln ln[100/(100-Q)] =0.694 0 ln t-0.761 7,r =0.997 1,which was in line with the Weibull equation.CONCLUSION Norcantharidin temperature-sensitive in situ gel has a stable property and significant property of sustained-release in vitro.关键词
去甲斑蝥素/温敏型原位凝胶/体外释放Key words
norcantharidin/temperature-sensitive in situ gel/release in vitro引用本文复制引用
周峰,谢明华,周红琴,蔡鑫君,倪坚军,王增..去甲斑蝥素温敏型原位凝胶的制备及其体外释放特性[J].中国临床药学杂志,2017,26(3):177-180,4.基金项目
浙江省中医药科学研究基金计划(编号2016ZA038),杭州市科技发展计划项目(编号20140633B57),杭州市余杭区科技发展计划项目(编号2014003),浙江省中西医结合学会科研项目(编号2013LYZD007) （编号2016ZA038）
