中国美容医学2017，Vol.26Issue(6)：79-81,3.
脂肪干细胞降低光老化皮肤黑色素含量的实验研究
The Study on Adipose Derived Stem Cells to Reduce Skin Melanin Content of Photo-aging
隋冰 1王微 1李春阳 2张攀 2马旭 2李庆春2
作者信息
- 1. 黑龙江省森工总医院 黑龙江 哈尔滨 150040
- 2. 哈尔滨医科大学附属二院整形美容外科 黑龙江 哈尔滨 150001
- 折叠
摘要
Abstract
Objective To observe the efficacy of adipose derived stem cells (ADSCs) to reduce skin melanin content of photoaging. Methods The back skin of bilateral ears from 6-week old nude mice(18-22g) was exposed to the ultraviolet radiation once every two days, 30min each time. Four weeks later, the successful establishment of the photoaging model was determined by observing the skin changes and Fontana-Masson dyeing. The ADSCs was randomly injected into a side back subcutaneous area of ears using the micro syringe, while the other side was injected with equivalent Hank's Balanced Salt Solution (HBSS) as controls. Fontana-Masson stain was performed to observe the number of melanin in the skin. Results The number of melanin in ADSCs group was smaller than that of the control group, the difference was statistically significant(P<0.05). Conclusion Photoaging can lead to an increase in melanin content of skin. ADSCs can reduce the melanin content of photoaging skin.关键词
脂肪干细胞/黑色素/光老化/紫外线Key words
adipose derived stem cells(ADSCs)/melanin/photoaging/UVB分类
医药卫生引用本文复制引用
隋冰,王微,李春阳,张攀,马旭,李庆春..脂肪干细胞降低光老化皮肤黑色素含量的实验研究[J].中国美容医学,2017,26(6):79-81,3.
