摘要
Abstract
Objective Q-switched Nd: YAG laser (QSNY) is commonly used in the treatment of melasma, our current study aims to evaluate the efficacy and safety of TA combined with QSNY in treating melasma based on randomized controlled trials (RCTs). Methods A comprehensive literature search was performed in Pubmed, EMBASE, CENTRAL, ISI Web of Science, Wanfang and CNKI to identify the RCTs of TA in the treatment of melasma. Outcome assessments included clinically effective rate, recurrence rate and adverse effects. Meta-analysis was conducted via RevMan 5.3 software. Results Our current study included a total of 11 RCTs comprising 526 patients in QSNY/TA groups and 489 patients in QSNY groups. When compared with QSNY therapy, TA combined with QSNY showed significantly higher clinically effective rate (RR 1.98,95%CI 1.74,2.26), significantly fewer adverse effects (RR 0.38,95%CI 0.24,0.62) and significantly lower recurrence rate (RR 0.36,95%CI 0.16, 0.77). Conclusion TA combined with QSNY was better than QSNY alone in treating melasma, evidenced by significantly higher clinically effective rate, significantly reduced recurrence rate and fewer adverse events.关键词
氨甲环酸/Q开关Nd:YAG1064nm激光/黄褐斑/Meta分析Key words
tranexamic acid/Q-switched Nd: YAG laser/melasma/meta-analysis分类
医药卫生
