中国美容医学2017，Vol.26Issue(6)：137-139,3.
非节段型白癜风患者黑素细胞自噬及脱落的研究进展
Study on the Correlation between Melanocyte Autophagy and Melanocytorrhagy on Non-segmental Vitiligo Patients
胡孟娇 1武松江2
作者信息
- 1. 南华大学 湖南 衡阳 421001
- 2. 南华大学附属第一医院皮肤科 湖南 衡阳 421001
- 折叠
摘要
Abstract
Vitiligo due to the loss of melanocytes in the epidermis or dysfunction of the formation of clinical common pigmentation spots, the specific mechanism has not yet fully elucidated. Recent studies of melanocytic autophagy and melanocytorrhagy have matured.Low level of autophagy may damage the melanocyte antioxidant defense system leading to vitiligo. Researchers who support for melanocyte shedding theory pointed out that non-segmental vitiligo(NSV) Epithelial cadmium(Ecad) within the epidermis mediated intercellular adhesion abnormalities, which can cause melanocytes and adjacent keratinocytes between Adhesion defects, then combined with mechanical stress and other effects through the impact of a variety of intracellular signals, melanocytes from the base layer to escape, and ultimately lost through the epidermis. This article will make an overview about the research progress of melanocyte autophagy and melanocyte shedding, and the possible correlation between the two theories.They may provide a direction for the pathogenesis of non-segmental vitiligo and targeted therapy.关键词
黑素细胞自噬/黑素细胞脱落/白癜风Key words
melanocyte autophagy/melanocytorrhagy/non-segmental vitiligo分类
医药卫生引用本文复制引用
胡孟娇,武松江..非节段型白癜风患者黑素细胞自噬及脱落的研究进展[J].中国美容医学,2017,26(6):137-139,3.
