中国全科医学2017，Vol.20Issue(19)：2347-2352,2357,7.DOI:10.3969/j.issn.1007-9572.2017.19.011
老年冠心病患者合并衰弱综合征的影响因素研究
Associated Factors for the Identification of Frailty Syndrome in Coronary Heart Disease in the Elderly
摘要
Abstract
Objective To investigate the associated factors for the identification of frailty syndrome in coronary heart disease(CHD) in the elderly,so as to provide a reference for the construction of a frailty model to develop diagnostic criteria for frailty in China.Methods The enrolled participants were 365 hospitalized elderly patients with CHD who received treatment in Cardiovascular Department,the First Affiliated Hospital of Xinjiang Medical University from December 1,2015 to May 30,2016.Based on the frailty status assessed by the Fried Frailty henotype,the participants were divided into nonfrail group(n=251),prefrail group(n=66) and frail group(n=48).The comparison of clinical data was made between the groups.Multivariate Logistic regression analysis was performed to investigate the associated factors for the identification of frailty syndrome in the participants.Results The three groups differed significantly in terms of age,BMI,proportion of patients with specific markers of severe CHD,ratios of patients with concomitant disorders such as diabetes,chronic obstructive pulmonary disease(COPD),congestive heart failure,chronic renal insufficiency,tumor,Alzheimer's disease,hyperuricemia,arrhythmia,valvular heart disease in the elderly,and pulmonary infection(all P<0.05).Notable differences were found between the groups in the levels of serum interleukin-6(IL-6),C-reactive protein(CRP),fibrinogen(FIB),brain natriuretic peptide(BNP),uric acid(UA),serum creatinine(Scr),Cystatin C(Cys C),albumin(ALB),hemoglobin(Hb),white blood count(WBC) and neutrophil count(all P<0.05).Results of multivariate Logistic regression analysis showed that,age,concomitant tumor,levels of BNP,BNP,UA,Scr,ALB and neutrophil count were significantly associated with the identification of frailty syndrome in participants in prefrail group and frail group(P<0.05);concomitant COPD,concomitant tumor,levels of IL-6,UA,Scr and ALB were substantially associated with the identification of frailty syndrome in participants in nonfrail group and frail group(P<0.05).Conclusion Age,concomitant disorders such as COPD and tumor,levels of IL-6,BNP,UA,Scr,ALB and neutrophil count are significantly associated with the identification of frailty syndrome in elderly patients with CHD,which can be referred to in the construction of a frailty model to develop diagnostic criteria for frailty as well as making relevant personalized diagnosis and treatment decisions.关键词
冠心病/衰弱综合征/影响因素分析/老年人Key words
Coronary disease/Frailty syndrome/Root cause analysis/Aged分类
医药卫生引用本文复制引用
曾朝霞,梁杰..老年冠心病患者合并衰弱综合征的影响因素研究[J].中国全科医学,2017,20(19):2347-2352,2357,7.基金项目
新疆维吾尔自治区自然科学基金资助项目(2016D01C303) （2016D01C303）
