中国全科医学2017，Vol.20Issue(19)：2378-2382,5.DOI:10.3969/j.issn.1007-9572.2017.19.016
HHIP基因多态性与新疆哈萨克族慢性阻塞性肺疾病易感性的关系研究
Relationship between HHIP Gene Polymorphism and Chronic Obstructive Pulmonary Disease Susceptibility in Kazakh Population in Xinjiang,China
摘要
Abstract
Objective To explore the relationship of two single nucleotide polymorphisms(SNPs),rs13118928 and rs1828591,of HHIP gene with chronic obstructive pulmonary disease (COPD) susceptibility in Kazakh population in Xinjiang,China.Methods The participants enrolled were 214 inpatients and outpatients(case group) who received treatment of department of respiratory medicine,and 350 healthy controls(control group) underwent physical examination,in Ili Kazak Autonomous Prefecture Friendship Hospital,Xinhua Hospital,and the First Affiliated Hospital of the Medical College,Shihezi University from October 2014 to May 2016.Pulmonary function measurement apparatus produced by an American company,Medgraphics Corp.was used to measure the forced vital capacity(FVC),forced expiratory volume in one second (FEV1),FEV1% predicted,and FEV1/FVC ratio.The imLDRTM technique for SNP genotyping was used to detect the polymorphisms of HHIP gene in peripheral venous blood cells.Results The patterns of genotype and allele frequencies of rs13118928 at the HHIP locus did not differ significantly between the groups(P>0.05).The patterns of genotype and allele frequencies of rs1828591 at the HHIP locus in the case group were not obviously different from those of in the control group(P>0.05).FEV1% predicted and FEV1/FVC ratio did not differ substantially between the patients in the case group by rs13118928 genotypes(P>0.05).No differences in FEV1% predicted and FEV1/FVC ratio were found between the patients in the case group by rs1828591 genotypes(P>0.05).The groups did not display notable differences in the patterns of haplotype frequencies for rs13118928 and rs1828591 at the HHIP locus(P>0.05).Conclusion The two SNPs (rs13118928 and rs1828591) at the HHIP gene locus have no significant correlation with COPD susceptibility in Kazakh population in Xinjiang,China.关键词
肺疾病,慢性阻塞性/HHIP基因/多态性,单核苷酸Key words
Pulmonary disease/chronic obstructive/HHIP gene/Polymorphism/single nucleotide分类
医药卫生引用本文复制引用
成芳娟,关键,任侠,马程远..HHIP基因多态性与新疆哈萨克族慢性阻塞性肺疾病易感性的关系研究[J].中国全科医学,2017,20(19):2378-2382,5.基金项目
国家自然科学基金资助项目(81560009) （81560009）
