摘要
Abstract
Objective To estimate the correlation of 3 kinds of serum vitamin(E,carotene β and A) levels involved in oxidative stress injury with the mortality in primary liver cancer patients with radical hepatic carcinectomy.Methods The participants enrolled in this study were 198 consecutive primary liver cancer patients treated by radical hepatic carcinectomy in Tianyou Hospital Affiliated to Wuhan University of Science & Technology from January 2010 to January 2013.Based on the survival status found at the end of 3-year follow-up period,they were divided into the survival group(n=101) and death group(n=97).The serum vitamin(E,carotene β and A) levels and oxidative stress markers〔total anti-oxidative status(TAS),total oxidative status(TOS) and oxidative stress index(OSI)〕 of the participants were measured at 1,and 3 months after the surgery and the difference between the two measured values of the above items(△VitE,△Vitcarotene β,△VitA,△TOS,△TAS and △OSI) were calculated.Results Compared with the survival group,the death group had lower serum vitamin E values measured at the time of 3 months after the surgery,less △VitE,less △VitA(P<0.05).The TAS measured at the time of 3 months after the surgery was lower,△TAS and △TOS and △OSI values were all less,but TOS and OSI measured at the time of 3 months after the surgery were higher in the death group than in the survival group(P<0.05).For predicting the postoperative 3-year mortality,the AUC value of serum vitamin E measured at the time of 3 months after surgery was 0.798〔95%CI(0.716,0.894)〕,and that of △VitE was 0.894〔95%CI(0.735,0.934)〕.In all the participants,a positive correlation existed between serum vitamin E and TAS measured at the time of 3 months after surgery(r=0.521,P<0.05),while a negative correlation existed between serum vitamin E and mortality(r=-0.611,P<0.05),and a negative correlation was found between serum vitamin E measured at the time of 3 months after surgery and mortality(r=-0.653,P<0.05).Multivariate Logistic regression analysis found that,the independent influencing factors for postoperative 3-year mortality in the participants were serum vitamin E value measured at the time of 3 months after surgery >10.1 μmol/L〔OR=0.78,95%CI(0.40,0.98),P<0.05〕 and △VitE >0.6 μmol/L〔OR=0.89,95%CI(0.49,0.99),P<0.05〕.Conclusion The serum vitamin E value measured at the time of 3 months after surgery may be a potential predictor for the postoperative 3-year mortality in primary liver cancer patients with radical hepatic carcinectomy.关键词
肝肿瘤/维生素E/β胡萝卜素/维生素A/死亡率Key words
Liver neoplasms/Vitamin E/Beta carotene/Vitamin A/Mortality分类
医药卫生
