中国人兽共患病学报2017，Vol.33Issue(5)：398-402,422,6.DOI:10.3969/j.issn.1002-2694.2017.05.003
中国西北四省(区)结核分枝杆菌分离株一线药物耐药状况及其影响因素分析
First-line drugs resistance of Mycobacterium tuberculosis isolated from inpatients and its influencing factors in the four provinces of northwestern China
摘要
Abstract
In this study,we investigated the status of the first-line drugs resistance (DR) of Mycobacterium tuberculosis (MTB) and its influencing factors in the four provinces of northwestern China to provide basic scientific evidence for the prevention and control of drug-resistant tuberculosis (TB).A total of 757 clinical MTB isolates from the sputum specimens of the patients with TB in 2005-2011 from four provinces and the autonomous regions (Gansu,Tibet,Xinjiang,Inner Mongolia) of Northwest China were collected.The drug susceptibility of these clinical isolates to the four first-line drugs streptomycin (SM),rifampicin (RFP),isoniazid (INH) and ethambutol (EMB) was determined by means of the drug susceptibility test (DST) of proportion method,The related influencing factors of DR-TB were analyzed by x2 analysis with case background data.Of 757 clinical MTB isolates tested with DST,the percentages of drug resistance to SM,RFP,INH and EMB were 28.14％,26.68％,26.02％ and 7.53％,and the total drug resistance rate and multi-drug resistance (MDR) rate were 40.55％ and 18.63％,respectively.The total drug resistance rate and MDR rate of Tibet,Xinjiang,Gansu and Inner Mongolia were 64.42％ and 42.94％,40.48％ and 23.81％,41.61％ and 3.36％,27.90％ and 11.29％,respectively.The statistical x2 analysis results showed that there were significant differences in drug resistance rate to RFP,INH and SM and MDR rate in these provinces (P＜0.05).Logistic regression analysis results showed that the influence factors were the case types.The risk of drug resistance in retreatment cases was 2.582 times (95％CI:1.882-3.737) than that in the initial treatment cases.The status of MDR is serious in the northwestern China,especially in Tibet and Xinjiang.Strengthening surveillance of drug resistance and standardized and whole course treatment of TB to prevent the disease recurrence are the key measures for the better prevention and control of drug resistant TB.关键词
结核分枝杆菌/耐药性/一线抗结核药物/Logistic回归分析Key words
Mycobacterium tuberculosis/drug-resistance/the first-line drugs against tuberculosis/logistic regression analysis分类
医药卫生引用本文复制引用
李雨睛,万李,陈杏,刘海灿,蒋毅,赵秀芹,管茶香,万康林,袁秀琴..中国西北四省(区)结核分枝杆菌分离株一线药物耐药状况及其影响因素分析[J].中国人兽共患病学报,2017,33(5):398-402,422,6.基金项目
国家科技重大专项(2013ZX10003002-001)Funded by the National Science and Technology Major Project of China (No.2013ZX10003002-001) （2013ZX10003002-001）
