中国人兽共患病学报2017，Vol.33Issue(5)：436-440,5.DOI:10.3969/j.issn.1002-2694.2017.05.010
贵州省2010-2015年克-雅病病例监测结果分析
Surveillance of Creutzfeldt-Jakob diseases cases in Guizhou Province,China, 2010-2015
蒋维佳 1韩璐 2熊洁 3蔡立君 3焦玲 3黄荷 1李世军 1刘艳 4朱英武 3徐竹 3孙美璐 3方旭明3
作者信息
- 1. 贵州省疾病预防控制中心传防所,贵阳 550004
- 2. 贵州省人民医院神经内科,贵阳550004
- 3. 贵州省医科大学附属医院神经内科,贵阳 550004
- 4. 贵州省第二人民医院神经内科,贵阳 550004
- 折叠
摘要
Abstract
We analyze the epidemiology,clinical features,and outcome of the patients with Creutzfeldt-Jakob diseases (CJD) in Guizhou Province from 2010 to 2015.The epidemiology,clinical characteristics and follow-up data of CJD suspected patients obtained from Guizhou CJD surveillance network were analyzed.The testing results of cerebrospinal fluid (CFS) and blood from the patients were also collected and analyzed.Results showed that a total of 11 CJD cases was found from 23 reported CJD suspected patients in Guizhou from 2010 to 2015,including 8 probable sporadic CJD(sCJD) cases,2 possible sCJD cases and 1 genetic CJD(gCJD) case.In 11 cases,rapidly progressive dementia was the major initial symptom,following by mental symptoms,extrapyramidal symptoms,signs and cerebellum cortical blindness.Clinical symptoms of progressive dementia were the main symptoms,following by visual or cerebellar dysfunction,myoclonus,cone system/extrapyramidal dysfunction,and akinetic mutism.Most of cases were abnormal in MRI (45.45％) and 14-3-3 protein detection in CSF(70％).The 14-3-3 blood samples of prion gene 129 amino acids (PRNP)polymorphisms were M/M type,excepting for 1 case gCJD confirmed diagnosis cases with D178N mutation in PRNP gene.Eleven CJD cases did not show season and regional clusterings and vocational tendency.The majority of the cases were male,the median age was 65,and mainly were the Han nationality.For all cases of CJD reported during that year for follow-up,the lost-tofollow-up rate was 27％,and the majority of cases died within one year.The sCJD cases were the majority in CJD cases of Guizhou Province,2010-2015.The epidemiological characteristics were similar to the national monitoring cases in the same period.关键词
克-雅病/监测/特征Key words
CJD/monitoring/characteristics分类
医药卫生引用本文复制引用
蒋维佳,韩璐,熊洁,蔡立君,焦玲,黄荷,李世军,刘艳,朱英武,徐竹,孙美璐,方旭明..贵州省2010-2015年克-雅病病例监测结果分析[J].中国人兽共患病学报,2017,33(5):436-440,5.
