中国实验动物学报2017，Vol.25Issue(3)：256-262,7.DOI:10.3969/j.issn.1005-4847.2017.03.005
钙螯合胶原多肽与雌激素对去卵巢大鼠骨质改善作用的比较
Comparison of the ameliorating effect of collagen peptide chelated calcium and estrogen on the bone quality in ovariectomized rats
摘要
Abstract
Objective To compare the ameliorating effect of collagen peptide chelated calcium (CPCC) and estrogen on the bone quality in ovariectomized rats in order to serve the development of safe drugs for prevention of osteoporosis (OP).Methods Bilateral ovariectomized rats were divided into ovariectomized group (OVX),sham group,17β-estradiol injection group (OVX+E2) and CPCC gavage group (OVX+CCCP).Bone and serum indices of these groups were assessed and compared at 9 weeks after treatment.Results Bone density of the OVX group was significantly lower than the sham group (P<0.01),indicating that the rat OP model was successfully established.Like estrogen,CPCC inhibited the abnormal changes of all indices and maintain similar levels with those of the sham group (P>0.05),while the body weight gain of the E2 group at weeks 8 and 9 was significantly lower than those of the sham group (P<0.01).As regarding the prevention of bone loss,the Mg and Ca levels of the E2 group were significantly lower than those of the moderate and high dose CPCC groups.The Cu level was not significantly different compared with the sham group,while those in the moderate and low dose CPCC groups were significantly higher than the sham group.The Mn,Zn and hydroxyproline levels of the E2 group were significantly lower than those of the sham group,while the CPCC group maintained levels similar to that of the sham group.In regarding to the inhibiting effect on the increased blood BGP and StrACP,the E2 group was still maintained at levels similar to that of the OVX group,while those of the CPCC group were significantly lower than the OVX group.As regarding the decreased blood Ca,the E2 group was not significantly different with that of the OVX group,while that of the CPCC group was significantly higher than the OVX group.Conclusions CPCC is more effective than estrogen in ameliorating the bone quality of ovariectomized rats.关键词
钙螯合胶原多肽/17β-雌二醇/去卵巢大鼠/骨质疏松Key words
Collagen peptide chelated calcium/17β-estradiol/Osteoporosis/Ovariectomized rats分类
生物科学引用本文复制引用
高文伟,申勇涛,程稚玲,韩克光,霍乃蕊..钙螯合胶原多肽与雌激素对去卵巢大鼠骨质改善作用的比较[J].中国实验动物学报,2017,25(3):256-262,7.基金项目
国家自然科学基金(编号:31201347) （编号:31201347）
山西省回国留学人员项目(编号:2014-042). （编号:2014-042）
