中国实验动物学报2017，Vol.25Issue(3)：270-274,5.DOI:10.3969/j.issn.1005-4847.2017.03.007
Roux-en-Y胃旁路术对2型糖尿病大鼠肝及外周胰岛素敏感性的影响
Roux-en-Y gastric bypass increases hepatic and peripheral insulin sensitivity in rats with type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the effects of Roux-en-Y gastric bypass (RYGB) on hepatic and peripheral insulin sensitivity in rats with type 2 diabetes and their possible mechanisms.Methods 5-6 week old SPF male Sprague-Dawley rats were divided into 2 groups: diabetic RYGB group (n=21) and diabetic RYGB sham group (n=7).The hyperinsulinemic-euglycemic clamp with tracer infusion was completed at 2,4,and 8 weeks postoperatively to assess the insulin sensitivity.The lipid content in liver and muscle tissue was examined.Results Postoperatively,the diabetic RYGB group had significant decreases in weight,fat mass,and RYGB had a profound effect on the plasma lipid profile.Two weeks after surgery,the hepatic insulin sensitivity index was significantly improved and the hepatic triglyceride was decreased in the RYGB group (P<0.05).The significant increased insulin sensitivity was not detected until four weeks after RYGB surgery,the M value was significantly increased and the TG content in the muscle tissue was significantly decreased (P<0.05).Conclusions The increased insulin sensitivity after RYGB occurs earlier in the liver than in the muscle and both may contribute to the long-term remission of type 2 diabetes.Reduced lipid content in hepatocytes and skeletal muscle cells after RYGB may contribute to the improved insulin sensitivity in these cells.关键词
2型糖尿病/肥胖/胰岛素抵抗/Roux/胰胃旁路术Key words
Type 2 diabetes mellitus/Obesity/Insulin resistance/Roux-en-Y gastric bypass/Rats分类
生物科学引用本文复制引用
刘红媛,马南希,马瑞,何冰..Roux-en-Y胃旁路术对2型糖尿病大鼠肝及外周胰岛素敏感性的影响[J].中国实验动物学报,2017,25(3):270-274,5.基金项目
国家自然基金面上项目(NO.81570765) （NO.81570765）
辽宁省科学技术基金(NO.2015020539). （NO.2015020539）
