中国实验动物学报2017，Vol.25Issue(3)：329-335,7.DOI:10.3969/j.issn.1005-4847.2017.03.018
基因修饰工具猪模型的建立及应用
Establishment and application of genetically modified pig tool models
摘要
Abstract
Genetically modified tool animal models are the animal models,which are generated by modifying a defined gene and can be used as a tool to help realize other objective.Genetically modified large animals have wide applications in agriculture and biomedicine.Tool animal models play important role in biological research and development of new drugs in biomedicine,especially,have made tremendous contribution in revealing gene function and pathway of signal transduction.Pigs are not only an economically important agriculture animals,but also an ideal animal model in biomedicine due to its close similarity to human in physiology,as well as organ structure and size.Thanks to the breakthrough of newly emerged gene editing technology,striking progress has made in establishment of genetically modified tool pig models which include the ones used for monitoring pluripotency of cells,tracing cell lineages,replacing genes mediated by Cre recombinase,mimicking immunodeficiency,as well as gene editing in vivo.These tool models have been widely applied in biological research.Here,we will review the progress in generation of genetically modified tool pig models and their applications.关键词
猪/基因修饰/工具Key words
Pigs/Gene modification/Tool pig models分类
生物科学引用本文复制引用
李小平,王可品,刘琪帅,赖良学..基因修饰工具猪模型的建立及应用[J].中国实验动物学报,2017,25(3):329-335,7.基金项目
国家自然科学基金(编号:81672317,81671121). （编号:81672317,81671121）
