中国比较医学杂志2017，Vol.27Issue(6)：1-5,5.DOI:10.3969.j.issn.1671-7856.2017.06.001
食蟹猴自发性高血压及患病危险性的相关性研究
Spontaneous hypertension in cynomolgus monkeys and an analysis of its risk factors
摘要
Abstract
Objective To establish reference values for blood pressure in cynomolgus monkeys in different ages.Methods The blood pressures and blood lipids indexes were detected in 521 cynomolgus monkeys using an American BECKMAN-CX4 automatic biochemical analyzer and a wrist electronic blood pressure monitor.Statistical tests were performed to analyze the data.Results Significant differences were found in blood pressure values of cynomolgus monkeys in different ages.Blood pressure values in the elderly group were higher than those of other groups.The morbidity of hypertension in the elderly group was higher than those of the other groups.Body mass index (BMI) in the hypertension group was higher than that of normal group in the same age.The incidence of hypertension in the elderly group with hyperlipemia was higher than that of other groups.Logistic regression analysis showed that age, BMI and hyperlipidemia in the hypertensive group were 1.435, 1.218, and 2.337 times higher than those of the normal group when predicting the risk of hypertension.Conclusions We have initially established reference values of blood pressure in cynomolgus monkeys in different ages.Age, BMI and hyperlipidemia are risk factors of spontaneous hypertension in cynomolgus monkeys, and the measurement of blood pressure may provide a basis for the screening of cynomolgus monkey model of spontaneous hypertensive and related research.关键词
食蟹猴/高血压/BMIKey words
Cynomolgus monkeys/Hypertension/BMI分类
医药卫生引用本文复制引用
徐湘婷,韦祝梅,李振明,罗绍忠,向黎,张常弘,杨继红,杨淬..食蟹猴自发性高血压及患病危险性的相关性研究[J].中国比较医学杂志,2017,27(6):1-5,5.基金项目
国家"十二五"重大新药创制专项(编号:2011ZX09307-303) （编号:2011ZX09307-303）
广西科技计划项目(编号:桂科能14123006-7) （编号:桂科能14123006-7）
广西科技计划项目(编号:桂科攻1347003-3). （编号:桂科攻1347003-3）
