中国实用内科杂志2017，Vol.37Issue(6)：496-498,3.DOI:10.19538/j.nk2017060106
干燥综合征肝损害
Liver damage in Sj(o)gren's syndrome
摘要
Abstract
Sj(o)gren's syndrome (SS) is a connective tissue disease characterized by the invasion to lacrimal glands and salivary glands.Liver damage is one of the common complications.There are many causes and it is generally believed that the pathogenesis is due to the infiltration of lymphocytes and plasmocyte to the hepatic portal,which leads to humoral and cellular immune abnormalities,releasing a variety of inflammatory mediators to cause tissue inflammation and destruction.Clinical manifestations are not specific.SS is closely related to autoimmune liver disease,but there is no unified conclusion about these two kinds of liver damage at present.Corticosteroids can quickly improve clinical symptoms and laboratory results.Immunosuppressant can be used in patients with rapid progression.Few studies have been done on the effects of rituximab on SS liver damage.Ursodeoxycholic acid is commonly used in the treatment of SS complicated with primary biliary cirrhosis.关键词
干燥综合征/肝损害/原发性胆汁性肝硬化/自身免疫性肝炎Key words
Sj(o)gren's syndrome/liver damage/primary biliary cirrhosis/autoimmune hepatitis分类
医药卫生引用本文复制引用
陈欢雪,王晓非..干燥综合征肝损害[J].中国实用内科杂志,2017,37(6):496-498,3.基金项目
辽宁省科学计划项目(2014225017) （2014225017）
