中国实用内科杂志2017，Vol.37Issue(6)：499-502,4.DOI:10.19538/j.nk2017060107
原发性干燥综合征肾脏损害临床特点及诊治对策
Clinical characteristics and strategies of diagnosis and treatment of renal involvement in primary Sj(o)gren's syndrome
郑辉 1杨程德2
作者信息
- 1. 上海交通大学医学院附属瑞金医院风湿免疫科,上海200025
- 2. 泰山医学院附属医院,山东泰安271000
- 折叠
摘要
Abstract
Primary Sj(o)gren's syndrome (pSS) is an autoimmune disease that mainly affects the exocrine glands and results in sicca symptoms (dryness of the eyes and mouth).Systemic complications can occur in pSS,but renal involvement is rare.The most frequent form of nephropathy in pSS is tubulointerstitial nephritis (TIN) and membranoproliferative glomerulonephritis (MPGN) secondary to cryoglobulinaemia.The combination of steroids,immunosuppressants or rituximab,plasma exchange can be used as the treatment choice in MPGN secondary to cryoglobulinaemia.For patients with TIN,steroid therapy (≥0.5 mg/kg per day) is an efficient option.The value ofimmunosuppressants or rituximab in the treatment of TIN is still in debate.关键词
干燥综合征/肾脏损害/肾小管间质性肾炎/膜增生性肾小球肾炎Key words
Sj(o)gren syndrome/nephropathy/tubulointerstitial nephritis/membrane proliferative glomerulonephritis分类
医药卫生引用本文复制引用
郑辉,杨程德..原发性干燥综合征肾脏损害临床特点及诊治对策[J].中国实用内科杂志,2017,37(6):499-502,4.
