中国实用外科杂志2017，Vol.37Issue(6)：619-624,6.DOI:10.19538/j.cjps.issn1005-2208.2017.06.07
低位直肠癌新辅助治疗后临床完全缓解病人处理策略
Management of clinical complete response after neoadjuvant chemoradiotherapy in low rectal cancer
摘要
Abstract
Neoadjuvant chemoradiotherapy (CRT) followed radical surgery including total mesorectal excision (TME) is standard treatment in patients with locally advanced rectal cancer.The benefits of neoadjuvant CRT have been well documented and include tumor regression and downstaging associated with increased tumor respectability,reduced local recurrence and a higher rate of sphincter preservation.Radical surgery for rectal cancer carries a high risk of morbidity and mortality and can also greatly detract from a patient's quality of life.In light of the significant response rates that can be achieved with preoperative CRT,some scholars have suggested limiting further surgical therapy to local excision or just wait and see.Recently,several studies have explored the feasibility and efficacy of organ-preserving strategies for low rectal cancer.Therefore,it's a new challenge for clinician to choose how to treat the situation with clinical complete response after neoadjuvant therapy for low rectal cancer patients.关键词
直肠癌/新辅助治疗/完全缓解/等待观察/局部切除Key words
rectal cancer/neoadjuvant chemoradiotherapy/complete response/wait-and-see/local excision分类
医药卫生引用本文复制引用
罗双灵,康亮..低位直肠癌新辅助治疗后临床完全缓解病人处理策略[J].中国实用外科杂志,2017,37(6):619-624,6.基金项目
广东省科技计划项目(No.20138022000060) （No.20138022000060）
中山大学临床医学研究5010计划项目(No.2016005) （No.2016005）
中央高校基本科研业务费专项资金资助(No.16ykjc25) （No.16ykjc25）
