中国现代医学杂志2017，Vol.27Issue(10)：35-39,5.DOI:10.3969/j.issn.1005-8982.2017.10.007
邱氏穴对肾绞痛大鼠模型肾组织PGI2、TXA2和5-HT表达的影响
Effect of Qiu's point on expressions of PGI2, TXA2 and 5-HT in rat model of renal colic
摘要
Abstract
Objective To observe the effect of Qiu's point on the expressions of PGI2,TXA2 and 5-HT in the rats with renal colic.Methods The SD rats were randomly divided into three groups:normal group,model group and Qiu's point group.In the model and Qiu's point groups,1％ ethylene glycol and 1％ ammonium chloride were used as lure stone agents to establish the renal colic model induced by calcium oxalate stone in 10 days.The rats in the Qiu's point group were given acupuncture on Qiu's point with dragon-tiger fighting needling method.Then the behavior and pathological changes of kidney tissues were observed in the three groups,and the expressions of TXA2,PGI2 and 5-HT in the renal tissues were detected.Results The pain threshold value,the spontaneous pain score and the expressions of TXA2,PGI2 and 5-HT of the normal and Qiu's point groups were significantly lower than those of the model group (P ＜ 0.05);however,there was no significant difference in the TXA2,PGI2 or 5-HT expression between the normal group and the Qiu's point group (P ＞ 0.05).The PGI2/TXA2 ratio was significantly different between the Qiu's point group and the normal group (P ＜ 0.05),but not significantly different between the Qiu's point group and the model group (P ＞ 0.05).Conclusions Dragon-tiger fighting needling method on Qiu's point can achieve analgesic effect in the treatment with renal colic rats,the mechanism is perhaps inhibiting the synthesis of inflammatory mediators TXA2 and PGI2 and neurotransmitter 5-HT,and relieving the pain induced by 5-HT.关键词
邱氏穴/龙虎交战/肾绞痛/大鼠/作用机制Key words
Qiu's point/dragon-tiger fighting needling method/renal colic/rat/mechanism分类
医药卫生引用本文复制引用
王峻,肖扬,粱小兴,刘鸿,王志刚,孟磊,姚睿智,陈铭,邱云桥..邱氏穴对肾绞痛大鼠模型肾组织PGI2、TXA2和5-HT表达的影响[J].中国现代医学杂志,2017,27(10):35-39,5.基金项目
广州中医药大学第一附属医院创新强院工程项目(2015JY04) （2015JY04）
