中国现代医学杂志2017，Vol.27Issue(10)：47-51,5.DOI:10.3969/j.issn.1005-8982.2017.10.009
系统性红斑狼疮患者IL-37的表达及其与其他细胞因子的相关性
Expression of IL-37 and its correlations with other cytokines in patients with systemic lupus erythematosus
摘要
Abstract
Objective To study the levels of interleukin-37 (IL-37),interleukin-6 (IL-6),interleukin-18 (IL-18) and interferon-γ (IFN-γ) in serum and peripheral blood mononuclear cells of patients with systemic lupus erythematosus (SLE),and to investigate the relationships of IL-37 expression with other cytokines in the patients.Methods From December 2012 to December 2015,32 patients with SLE in the Department of Rheumatology,the First Hospital of Jilin University were selected into SLE group,and 32 normal healthy people in the Medical Examination Center were selected into control group.The serum levels of IL-37,IL-6,IL-18 and IFN-γ and the expressions of IL-37 mRNA,IL-6 mRNA,IL-18 mRNA and IFN-γ mRNA in the peripheral blood mononuclear cells were detected in both group.Results The serum levels of IL-37,IL-6,IL-18 and IFN-γ in the SLE group were significantly higher than those in the control group (P ＜ 0.05).The serum IL-37 was positively correlated with serum IL-6,IL-18 and IFN-γin the SLE patients (P ＜ 0.05).Multivariate regression analysis showed that the levels of IL-6,IL-18 and IFN-γwere the influencing factors for serum IL-37 level (P ＜ 0.05).The expressions of IL-37 mRNA,IL-6 mRNA,IL-18 mRNA and IFN-γ mRNA in the peripheral blood mononuclear cells of the SLE group were higher than those of the control group (P ＜ 0.05).The IL-37 mRNA expression in the peripheral blood mononuclear cells was positively correlated with the expressions of IL-6 mRNA,IL-18 mRNA and IFN-γ mRNA in the SLE patients(P ＜ 0.05).Multivariate regression analysis showed that IL-18 mRNA,IL-6 mRNA and IFN-γ mRNA expression levels were the influencing factors for IL-37 mRNA expression in the peripheral blood mononuclear cells (P ＜ 0.05).Conclusions The newly discovered inflammatory factor IL-37 is involved in the pathogenesis of systemic lupus erythematosus,and is associated with IL-6,IL-18 and IFN-γ.关键词
系统性红斑狼疮/白细胞介素37/白细胞介素6/白细胞介素18/干扰素-γKey words
systemic lupus erythematosus/interleukin-37/interleukin-6/interleukin-18/interferon-γ分类
医药卫生引用本文复制引用
高旗,马宁,赵令,刘涛,姜振宇..系统性红斑狼疮患者IL-37的表达及其与其他细胞因子的相关性[J].中国现代医学杂志,2017,27(10):47-51,5.基金项目
国家自然科学基金青年基金(No:81401332JC) （No:81401332JC）
