中国现代医学杂志2017，Vol.27Issue(10)：52-56,5.DOI:10.3969/j.issn.1005-8982.2017.10.010
SSTR2、Livin和Survivin在结肠癌组织中的表达及其意义
Expressions of SSTR2, Livin and survivin in colon carcinomas and their clinical significance
摘要
Abstract
Objective To investigate the expressions of SSTR2,Livin and survivin in normal mucous membrane of colon,colon adenoma,colon carcinomas and their adjacent tissues and the clinical significance.Methods The qRTPCR technique was utilized to detect the mRNA of SSTR2,Livin and survivin in colonic adenomas of 30 cases,colonic carcinomas and their adjacent tissues of 30 cases,and normal colon mucous membrane of 30 cases.Results The rates of positive expressions of Livin mRNA and survivin mRNA in the colon carcinomas were significantly higher than those in the colon adenomas (P ＜ 0.05).The expression rate of SSTR2 mRNA in the colon carcinomas was significantly lower than that in the colon adenomas (P ＜ 0.05).The expressions of Livin and survivin mRNA in the normal colon mucous membrane,the colon adenomas,the adjacent tissue of carcinomas,and the colon carcinomas had a gradually increased tendency,while the expressions of SSTR2 mRNA had a gradually decreased tendency.Conclusions SSTR2,Livin and survivin play important roles in the transition of colon mucosa from adenoma to cancer.关键词
SSTR2/Livin/Survivin/结肠腺瘤/结肠癌Key words
SSTR2/Livin/survivin/colon adenoma/colon carcinoma分类
医药卫生引用本文复制引用
王伟宁,徐赛群,刘丽,黄萍,潘佳,叶冠男,刘伟..SSTR2、Livin和Survivin在结肠癌组织中的表达及其意义[J].中国现代医学杂志,2017,27(10):52-56,5.基金项目
长沙市科技局计划项目(No:K1403059-31) （No:K1403059-31）
