中国现代医学杂志2017，Vol.27Issue(10)：71-75,5.DOI:10.3969/j.issn.1005-8982.2017.10.014
孕中期妊娠期糖尿病孕妇血清铁、锌和铁蛋白的变化情况及其与糖代谢指标的相关性
Changes of serum iron, zinc and ferritin in pregnant women with gestational diabetes during second trimester and their correlations with glucose metabolism indices
摘要
Abstract
Objective To study the changes of serum iron,zinc and ferritin in pregnant women with gestational diabetes in the second trimester,and to explore their correlations with gestational diabetes.Methods Totally 200 cases of pregnant women with gestational diabetes in the 24-28 gestational weeks in our hospital from January 2014 to December 2015 were selected as gestational diabetes group,while 200 pregnant women with normal blood glucose in the same gestational weeks as control group.Serum ferritin,iron and zinc levels and their correlations to sugar metabolism indexes were observed.Pregnancy iron deficiency,iron-deficiency anemia and fetal development were compared between the two groups.Results The fasting blood glucose,1-h glucose,2-h glucose,fasting insulin,glycated hemoglobin,insulin resistance index of the gestational diabetes group were higher than those of the control group (P ＜ 0.05).The pancreatic β cell function of the gestational diabetes group was significantly lower than that of the control group (P ＜ 0.05).The serum iron and ferritin levels in the gestational diabetes group were higher than those in the control group (P ＜ 0.05),while the serum zinc level was lower than that in the control group (P ＜ 0.05).The serum ferritin and iron levels were positively correlated with fasting glucose,fasting insulin,glycated hemoglobin and insulin resistance index (P ＜ 0.05).The serum zinc level was negatively correlated to serum fasting glucose,fasting insulin,glycated hemoglobin and insulin resistance index (P ＜ 0.05).There was no significant difference in the incidence of pregnancy iron deficiency or iron-deficiency anemia between the two groups (P ＞ 0.05).There was no significant difference in the fetal biparietal diameter,femur length,head circumference or abdominal circumference between the two groups (P ＞ 0.05).Conclusions During the second trimester of pregnancy,the levels of serum iron and ferritin increase and the level of serum zinc decreases in the pregnant women with gestational diabetes.The levels of serum iron,zinc and ferritin are significantly correlated to the sugar metabolism indexes in pregnant women with gestational diabetes,and to the incidence of gestational diabetes.关键词
妊娠期糖尿病/孕中期/铁/锌/铁蛋白Key words
gestational diabetes/the second trimester/iron/zinc/ferritin分类
医药卫生引用本文复制引用
张玲,王丽君..孕中期妊娠期糖尿病孕妇血清铁、锌和铁蛋白的变化情况及其与糖代谢指标的相关性[J].中国现代医学杂志,2017,27(10):71-75,5.基金项目
浙江省医药卫生项目(No:2014KYB027) （No:2014KYB027）
