中国现代医学杂志2017，Vol.27Issue(10)：117-122,6.DOI:10.3969/j.issn.1005-8982.2017.10.024
2013～2015年血流感染患者的病原体种类及耐药性分析
Species of pathogenic bacteria and drug resistance in patients with bloodstream infections: a 3-year analysis from 2013 to 2015
摘要
Abstract
Objective To investigate the distribution and antibiotic resistance of clinical isolates from blood culture,and to guide the rational use of antimicrobial agents.Methods Data of pathogens isolated from blood specimens of the patients with bloodstream infections in Tongling People's Hospital from 2013 to 2015 were statistically analyzed.Results Of the 595 strains isolated from blood samples,Gram-positive bacteria,Gramnegative bacteria and fungi accounted for 50.3％ (299/595),48.7％ (290/595) and 1.0％ (6/595) respectively.The top six pathogens were coagulase-negative Staphylococci (CNS,30.6％),E.coli (21.5％),Klebsiella (9.1％),Enterococcus spp (6.4％),S.aureus (SA,5.9％) and Baumannii spp (5.0％).Methicillin-resistant (MR) SA and MRCNS accounted for 34.3 ％ of S.aureus and 76.9 ％ of CNS,respectively.No strain was found resistant to Vancomycin,Teicoplanin or Linezolid in Staphylococcus spp.No strain was found resistant to Penicillin,Ampicillin,Vancomycin,Teicoplanin or Linezolid in E.faecalis.No strain was found resistant to Linezolid in E.faecium.Vancomycin-resistant and Teicoplanin-resistant E.faecium accounted for 23.5％ of the E.faecium isolates.About 50.8％ of the E.coli isolates and 38.9 ％ of the Klebsiella isolates produced extended-spectrum β-1actamases (ESBLs).Less than 1.0％ of the E.coli isolates,about 27.8 ％ of the Klebsiella isolates and 18.2％ of the Enterobacter spp.isolates,and more than 70.0％ of the Baumannii spp isolates were resistant to Carbapenems.Conclusions Gram-positive cocci are the major pathogens causing bloodstream infections in this hospital.CNS and E.coli are the most common pathogens.We should pay more attention to resistance surveillance and rational use of antibiotics.关键词
血流感染/抗菌药物/敏感性/细菌耐药性监测/多重耐药菌Key words
bloodstream infection/antimicrobial agent/antimicrobial susceptibility/bacterial resistance surveillance/multi-drug resistant bacterium分类
医药卫生引用本文复制引用
查翔远,潘晓龙,胡志军,宋有良,王谦,叶珍珠..2013～2015年血流感染患者的病原体种类及耐药性分析[J].中国现代医学杂志,2017,27(10):117-122,6.基金项目
铜陵市卫生和计划生育委员会科研项目(卫科研[2015]5号) （卫科研[2015]5号）
安徽省临床医学应用技术项目(No:2008A058) （No:2008A058）
