中国药房2017，Vol.28Issue(18)：2477-2480,4.DOI:10.6039/j.issn.1001-0408.2017.18.08
参松养心胶囊治疗脑干出血并发脑心综合征伴心律失常的临床观察
Clinical Observation of Shensong Yangxin Capsules in the Treatment of Brainstem Hemorrhage Complicat-ed with Cerebrocardiac Syndrome Accompanied by Arrhythmia
摘要
Abstract
OBJECTIVE:To observe therapeutic efficacy and safety of Shensong yangxin capsules in the treatment of brainsten hemorrhage complicated with cerebrocardiac syndrome(CCS)accompanied by arrhythmia. METHODS:Medical information of 98 patients with brainstem hemorrhage complicated with CCS arrhythmia were analyzed retrospectively and divided into control group (49 cases)and observation group(49 cases)according to drug use. Control group was given routine treatment as mannitol and pi-racetam. Observation group was additionally given Shensong yangxin capsules 1.2 g orally or via nasal feeding,3 times a day,on the basis of control group. Treatment course of 2 groups lasted for 4 weeks. Clinical efficacies of 2 groups were observed as well as the levels of catecholamine [norepinephrine(NE),epinephrine(E),dopamine(DA)],ET-1 and NO,the occurrence of ADR be-fore and after treatment. RESULTS:Total response rate of observation group was significantly higher than that of control group (75.5% vs. 46.93%),with statistical significance(P<0.05). Before treatment,there was no statistical significance in the levels of NE,E,DA,ET-1 and NO between 2 groups(P>0.05). 3 and 7 d after treatment,the levels of NE,E,DA,ET-1 and NO in 2 groups were significantly lower than before,and the observation group was significantly lower than the control group,with statisti-cal significance(P<0.05). There was no statistical significance in the incidence of ADR between 2 groups(P>0.05). CONCLU-SIONS:Based on routine treatment,Shensong yangxin capsules shows significant therapeutic efficacy for CCS,can reduce levels of catecholamine and doesn't increase the occurrence of ADR.关键词
脑干出血/脑心综合征/心律失常/参松养心胶囊/儿茶酚胺/疗效/安全性Key words
Brainstem hemorrhage/Cerebrocardiac syndrome/Arrhythmia/Shensong yangxin capsules/Catecholamine/Ther-apeutic efficacy/Safety分类
医药卫生引用本文复制引用
李伟,刘晓婷,李佳,李敬,许雪英,杨君..参松养心胶囊治疗脑干出血并发脑心综合征伴心律失常的临床观察[J].中国药房,2017,28(18):2477-2480,4.基金项目
河北省医学科学研究重点课题(No.2016326) （No.2016326）
