中国药房2017，Vol.28Issue(18)：2480-2482,3.DOI:10.6039/j.issn.1001-0408.2017.18.09
低分子肝素与利伐沙班预防老年患者骨折置换术后双下肢深静脉血栓的有效性和安全性比较
Comparison of Effectiveness and Safety of Low-molecular-weight-heparin and Rivaroxaban in Preventing Lower Extremity Deep Vein Thrombosis in the Elderly Patients after Surgery of Replacement of Fracture
摘要
Abstract
OBJECTIVE:To compare the effectiveness and safety of low-molecular-weight-heparin(LMWH)calcium and rivar-oxaban in preventing lower extremity deep venous thrombosis (DVT) in the elderly patients after surgery of replacement of frac-ture. METHODS:A total of 58 elderly patients underwent hip or artificial femoral head replacement were randomly divided into LMWH group (29 cases) and Rivaroxaban group (29 cases). All patients received basic prevention and physical prevention for DVT after surgery. Based on this,LMWH group was given Heparin calcium injection 4100 IU subcutaneously 10 h after surgery, for 10 d. Rivaroxabar group was given Rivaroxaban tablet 10 mg 10 h after surgery,once a day,for consecutive 10 d. The occur-rence of DVT and positive D-dimer were observed in 2 groups after surgery. The PT,APTT,TT,FIB and platelet counts abnormal-ity were also observed in 2 groups. RESULTS:There was no statistical significance in the incidence of DVT,the occarrence of pos-itive D-dimer,PT,APTT,TT,FIB and platelet counts abnormality 4,10 d after surgery between 2 groups(P>0.05). CONCLU-SIONS:LMWH and rivaroxaban both can be used for lower extremity DVT in the elderly patients after replacement of fracture sur-gery of and have similar therapeutic efficacy and safety.关键词
低分子肝素/利伐沙班/深静脉血栓/骨折置换术/疗效/安全性Key words
Low-molecular-weight-heparin/Rivaroxaban/Deep vein thrombosis/Surgery of replacement of fracture/Therapeu-tic efficacy/Safety分类
医药卫生引用本文复制引用
陆惠平,刘彦儒,高培培,龚婧如..低分子肝素与利伐沙班预防老年患者骨折置换术后双下肢深静脉血栓的有效性和安全性比较[J].中国药房,2017,28(18):2480-2482,3.基金项目
上海市卫生和计划生育委员会科研课题(No.20134422) （No.20134422）
