中国医学前沿杂志（电子版）2017，Vol.9Issue(5)：92-95,4.DOI:10.12037/YXQY.2017.05-18
亚低温治疗新生儿缺氧缺血性脑病临床效果研究
Effect of mild hypothermia therapy on neonatal hypoxic ischemic encephalopathy
摘要
Abstract
Objective To investigate the clinical effect of mild hypothermia therapy on neonatal hypoxic ischemic encephalopathy (HIE). Method From August 2013 to June 2016 in our hospital, according to the treatment methods, 40 neonate with HIE were prospectively collected as observation group. 47 neonate with HIE were collected as control group at the same time in our hospital. The traditional treatments were given to all neonates while at the same time, neonates in observation group received mild hypothermia treatment. All neonates were followed up to 6 months. The mortality, complications, neurological symptoms disappeared time, neonatal behavioral neurological assessment (NBNA) score, intelligence development index, motor development index of the two groups were studied and compared. Result There was no significant difference in mortality between the two groups (2.50% ︰ 6.38%, P = 0.389). At 1 month and 6 months since birth, intelligence development indexes of observation group neonates were higher than control group neonates [(91.57±7.57) ︰ (83.28±8.19), P = 0.000)] and [(95.38±9.56) ︰ (87.52±8.77), P = 0.000], neurological symptoms disappeared time of observation group neonates were shorter than control group neonates [(17.57±4.23) days ︰ (20.48±4.82) days, P = 0.004], motor development index of observation group neonates were higher than control group neonates [(88.65±6.62) ︰ (83.07±6.29), P = 0.000] and [(98.57±10.47) ︰ (91.82±9.18), P = 0.002]. There were no significant differences in NBNA scores between the two groups at the second day since birth [(25.63±6.36) ︰ (24.68±5.83), P = 0.472]. At 7 and 28 days since birth, NBNA scores of observation group neonates were higher than control group neonates [(33.83±5.93) ︰ (29.17±6.15), P = 0.001] and [(35.93±5.48) ︰ (32.83±5.54), P = 0.011]. There were no significant differences in incidence rates of complications between the two groups (P > 0.05). Conclusion Mild hypothermia therapy can significantly improve the neurological development of neonates with hypoxic ischemic encephalopathy, and it is safe and reliable.关键词
亚低温/新生儿/缺氧缺血性脑病/神经发育Key words
Mild hypothermia/Neonate/Hypoxic ischemic encephalopathy/Neurodevelopment引用本文复制引用
李炎,潘健崧,张文明,黎炽旺,林日亮,陈学馨,陈宏香..亚低温治疗新生儿缺氧缺血性脑病临床效果研究[J].中国医学前沿杂志（电子版）,2017,9(5):92-95,4.基金项目
广东省医学科学技术研究基金项目(B2015143) （B2015143）
梅州市科技局立项(2014B102) （2014B102）
