摘要
Abstract
Objective To investigate the effects of Gabapentin combined with Prednisone on immune function, levels of β-endorphin and cytokines in patients with postherpetic neuralgia. Method 95 patients with postherpetic neuralgia from March 2015 to March 2016 in Air Force General Hospital were selected as the subjects of study, they were randomly divided into observation group (48 cases) and control group (47 cases). Patients in control group were treated with Prednisone, and observation group patients were treated with Gabapentin on the basis of the treatment of control group. Two groups were treated for 2 weeks. The efficacy, immune function, β-endorphin, cytokine, visual analogue scale (VAS) scores before and after treatment and adverse reactions were compared between the two groups. Result The total effective rate of observation group was higher than control group (P < 0.05). After treatment, the levels of CD3+, CD4+ and CD4+/CD8+ in the two groups were significantly higher than those before treatment (P < 0.05), and the level of CD8+ was significantly lower than that before treatment (P < 0.05). The levels of CD3+, CD4+ and CD4+/CD8+ in observation group were significantly higher than control group (P < 0.05), and the level of CD8+was significantly lower than control group (P < 0.05). After treatment, the levels of plasma β-endorphin in the two groups were significantly increased (P < 0.05), and the level of plasma β-endorphin in observation group was significantly higher than control group (P < 0.05). After treatment, the level of serum tumor necrosis factor-α (TNF-α) in the two groups decreased significantly (P < 0.05), the level of interleukin-2 (IL-2) was significantly higher than that before treatment (P < 0.05); the serum TNF-α level in observation group was lower than control group (P < 0.05), the level of IL-2 was higher than control group (P < 0.05). After treatment, the VAS scores of the two groups were significantly lower than those before treatment (P < 0.05), and the score of VAS in observation group was lower than control group (P < 0.05). ECG, blood routine, urine routine, liver and kidney function were not abnormal in the two groups, and there was no serious adverse drug reaction. Conclusion Gabapentin combined with Prednisone for post-herpetic neuralgia, has a significant effect, its effect may be associated with improved immune function, increasing β-endorphin, improve inflammation, and security is good, is worth studying.关键词
加巴喷丁/泼尼松/带状疱疹后神经痛/免疫功能/β-内啡肽/细胞因子Key words
Gabapentin/Prednisone/Postherpetic neuralgia/Immune function/β-endorphin/Cytokine
