中国药业2017，Vol.26Issue(11)：19-22,4.DOI:10.3969/j.issn.1006-4931.2017.11.006
速溶阿胶颗粒生产工艺研究
Production Technology of Instant Colla Corii Asini Granules
于宗斌 1彭涛 1刘世琪1
作者信息
- 1. 太极集团重庆涪陵制药厂有限公司,重庆 408000
- 折叠
摘要
Abstract
Objective To study the industrialized production process of Colla Corii Asini Granules. Methods The technical parameters of microwave puffing were determined by the factor selection method, and the Colla Corii Asini power was made by extruding Colla Corii Asini power, the types and dosage of excipients were determined by random screening method, the granulating parameters were deter-mined by orthogonal test. Results The optimum conditions were as follows:the thickness of gelatin was less than 5 mm and the microwave heating time was 5 min. The formulation was Colla Corii Asini powder:the ratio of PVPP:CCMC-Na:MgSt was 1000 :50 :20 :1, the dry roll pressure of the dry roll was 60 kgf/cm2, the powder feeding speed was 20 r/min and the rotation speed was 10 r/min. Conclusion The results provide a basis for large-scale production.关键词
阿胶/速溶颗粒/真空微波干燥/制剂处方/干法制粒Key words
Colla Corii Asini/instant granules/vacuum microwave drying/preparation prescription/dry legal grain分类
化学化工引用本文复制引用
于宗斌,彭涛,刘世琪..速溶阿胶颗粒生产工艺研究[J].中国药业,2017,26(11):19-22,4.
