中国药业2017，Vol.26Issue(12)：7-10,4.DOI:10.3969/j.issn.1006-4931.2017.12.002
山楂酸对顺铂肾毒性的影响研究
Effect of Maslinic Acid on Cisplatin-Induced Nephrotoxicity
摘要
Abstract
Objective To investigate the effect of maslinic acid on Cisplatin-induced toxicity in kidney injury. Methods Renal tubular epithelial(HK-2)cells were selected. The experiment was divided into four groups:control group,Cisplatin group,maslinic acid protec-tion group(maslinic acid+Cisplatin),Vitamin E protection group(Vitamin E + Cisplatin). MTT was used to assess the viability of cell. Lactate dehydrogenase(LDH)was assessed to evaluate the kidney injury. Hochest 33342/PI was applied to determine the apoptosis of cell. Results After treatment of Cisplatin to HK-2 cell for 24 h,the viability of cell was significantly decreased,the release of LDH was increased,and the apoptosis of HK-2 cell was observed. However,when pretreatment of either maslinic acid or Vitamin E,the viability of cell was increased obviously,the release of LDH was decreased and the apoptosis of cell was decreased. Conclusion In HK-2 cells experiments,maslinic acid has protective effects on Cisplatin-induced toxicity.关键词
山楂酸/顺铂/肾损伤/乳酸脱氢酶Key words
maslinic acid/Cisplatin/kidney injury/lactate dehydrogenase分类
医药卫生引用本文复制引用
欧阳资章,朱少华,邬淑红,刘晓萍,常惠礼,麦露丝,肖诚胤..山楂酸对顺铂肾毒性的影响研究[J].中国药业,2017,26(12):7-10,4.基金项目
广东省清远市科技计划项目[ 2012B011204020 ]. （）
