中国药业2017，Vol.26Issue(12)：15-19,5.DOI:10.3969/j.issn.1006-4931.2017.12.004
甘草根和根茎的化学成分研究
Chemical Constituents of the Root and Rhizome of Glycyrrhiza Uralensis Fisch.
张杰 1李鸿钰 2徐丽丽 1曾铖 1李佑 1顾大全 1顾正兵1
作者信息
- 1. 江苏永健医药科技有限公司,江苏泰州 225300
- 2. 湖南省宁乡县人民医院,湖南长沙 410600
- 折叠
摘要
Abstract
Objective To study the chemical constituents in the root and rhizome of Glycyrrhiza Uralensis Fisch. . Methods Silica gel column chromatography was adopted,HPLC and recrystallization were used to isolate and purify,and the structures were identified by physical and chemical properties and spectral data. P-hydroxybenzylmalonic acid and naringenin-7- O-β-D-glucoside in Glycyrrhiza Uralensis Fisch. were determined by HPLC-DAD method for the first time. Results Eleven compouds were isolated and characterized as P-hydroxybenzylmalonic acid,liquiritin,neoliquiritin,isoliquiritin,neoisoliquiritin,naringenin-7- O-β-D-glucoside,ononin,liquiriti-napioside,isoliquiritin apioside,glycyrrhizin,isoliquiritigenin. P-hydroxybenzylmalonic acid was isolated from Glycyrrhiza Uralensis Fisch. for the first time in domestic,and naringenin-7- O-β-D-glucoside was isolated from Glycyrrhiza Uralensis Fisch. for the first time. P-hydroxybenzylmalonic acid and naringenin-7- O-β-D-glucoside had good linearity in the ranges of 0. 129-1. 29 μg, 0. 016-0. 16 μg,respectively. The average recoveries of the two constituents were 98. 47%,99. 08%,respectively. The RSDs were 1. 71%,1. 74%,respectively. Conclusion The method is simple and accurate,which can provide new reference for studying Glycyrrhiza Uralensis Fisch.关键词
甘草/化学成分/高效液相色谱-二极管阵列检测法/对羟基苄基丙二酸/柚皮素-7-O-葡萄糖苷Key words
Glycyrrhiza Uralensis Fisch./chemical constituents/HPLC-DAD/P-hydroxybenzylmalonic acid/naringenin-7- O-β-D-glucoside分类
医药卫生引用本文复制引用
张杰,李鸿钰,徐丽丽,曾铖,李佑,顾大全,顾正兵..甘草根和根茎的化学成分研究[J].中国药业,2017,26(12):15-19,5.
