摘要
Abstract
Objective To analyze the anti-proliferative effect of apigenin on lung cancer cells and its sensitization effect of anti-tumor drugs. Methods Totally 140 A/J mice of 5 weeks were selected and randomly divided into 3 groups,40 mice in the first group, 60 mice in the second group,40 mice in the third group,they were divided into the experimental group and the control group accord-ing to the digital random principle. In the rats aged 6-7 weeks,the experimental group in the first group and the second groups were intraperitoneally injected with 4-(methyl nitrosamine ) -1- (3-pyridine ) -1- butanone(NKK ) 10 mg/kg,and the control group in the first group was intraperitoneally injected with physiological saline. On the second and third day,the experimental group in the second group was treated with large doses of apigenin,the third group was given intraperitoneal injection of NKK. In the 52-62 weeks,the ex-perimental groups were given intragastric administration of apigenin at large doses,the control groups in the second group and the third group were treated with large doses of vegetable oil. In the fifty-second week,the mice in the first group and the second group were killed,and the mice in the third group were killed on the fifth day in the sixty-third weeks. The mice in the 3 groups were sacrificed and dissected to observe,and the lung cancer slices were treated with Oxaliplatin and Bleomycin. Results In the first group,an average of (1. 35 ± 0. 22)lung cancer lesions were found in the experimental group,and there were no cancer lesions in the control group. In the second group,only 2 mice in the experimental group were occasionally found the lung cancer lesions,and (1. 71 ± 1. 28 ) cancer le-sions were found in the control group. In the third group,(1. 01 ± 1. 19 ) cancer lesions were found in the experimental group,and (1. 56 ± 0. 78 ) cancer lesions were found in the control group. The CI were 0,(94. 32 ± 0. 27)% and (0. 36 ± 0. 03)% in the first,second and third group,respectively. Apigenin combined with Oxaliplatin and Bleomycin had synergistic reaction (CI was mostly less than 1 ) . Conclusion Apigenin plays an important role in the anti-proliferation of lung cancer cells and the sensitizing effect of anti-tumor drugs.关键词
芹菜素/肺癌细胞/抗增殖/抗肿瘤/增敏作用Key words
apigenin/lung cancer cells/anti-proliferative/anti-tumor/sensitization分类
医药卫生
