中国医院用药评价与分析2017，Vol.17Issue(6)：787-789,3.DOI:10.14009/j.issn.1672-2124.2017.06.025
小剂量替勃龙治疗妇女围绝经期综合征的疗效观察
Observation on Efficacy of Low-dose Tibolone in Treatment of Women in Perimenopausal Syndrome
蔡文莲 1杨彩文1
作者信息
- 1. 鄂州市妇幼保健院妇女保健科,湖北 鄂州 436000
- 折叠
摘要
Abstract
OBJECTIVE:To probe into the clinical efficacy of low-dose tibolone in treatment of women in perimenopausal syndrome.METHODS:140 patients with perimenopausal syndrome admitted into Ezhoumaternal and Child Health Care Hospital from Apr.2014 to Apr.2016 were extracted to be divided into control group and observation group via the double blind random number table,with 70 cases in each.The control group was given tibolone 2.5 mg/d,while the observation group received tibolone 1.5 mg/d,for 6 months.The total effective rate,incidence of adverse drug reactions during treatment,level of sex hormones before and after treatment in two groups were compared and observed.RESULTS:After treatment,the total effective rate of observation group was 94.29％(66/70),significantly higher than that of control group [84.29％(59/70)],with statistically significant difference(P<0.05).The incidence of adverse drug reactions in observation group was 7.14％(5/70),significantly lower than that in control group [17.14％(12/70)],with statistically significant difference(P<0.05).After treatment,the level of sex hormones in both groups had been improved significantly,and the observation group was better than the control group,with statistically significant difference(P<0.05).CONCLUSIONS:The efficacy of low-dose tibolone in treatment of women in perimenopausal syndrome is significant with few adverse drug reactions.关键词
替勃龙/围绝经期综合征/小剂量/不良反应Key words
Tibolone/Perimenopausal syndrome/Low dose/Adverse drug reactions分类
医药卫生引用本文复制引用
蔡文莲,杨彩文..小剂量替勃龙治疗妇女围绝经期综合征的疗效观察[J].中国医院用药评价与分析,2017,17(6):787-789,3.
