摘要
Abstract
OBJECTIVE:To investigate the incidence of adverse drug reactions(ADR)induced by antineoplastic drugs in People's Hospital ofmaanshan(hereinafter referred to as "our hospital"),so as to provide reference for clinical drug use.METHODS:Retrospective analysis was conducted on 257 cases of ADR induced by antineoplastic drugs during 2015-2016 in terms of gender and age,drug categories,administration route,involved organs and(or)systems and prognosis,etc.RESULTS:Of the 257 ADR cases,males were slightly more than females,the ratio of patients aged ≥50 years old with ADR was relatively high;there were 6 kinds of antineoplastic drugs involved,including 31 categories,cases of ADR induced by antineoplastic drugs and adjuvant therapy took the lead(119 cases,46.31％),followed by antineoplastic drugs of species source(52 cases,20.13％)and antimetabolites(50 cases,19.46％).The top 3 drugs were respectively oxaliplatin(44 cases,17.12％),cis-platinum(31 cases,12.06％)and gemcitabine(23 cases,8.95％).ADR induced by intravenous drip dominated the first place(233 cases,90.66％),followed by oral medication(12 cases,4.67％).ADR involved organs and(or)systems in 280 cases,and the most common were digestive system(114 cases,40.71％),hematological system(70 cases,25.00％)and skin and its accessories(43 cases,15.36％).Cases of general ADR and severe ADR took the lead,after timely withdrawal and expectant treatment,patients were cured or recovered,without any death cases.CONCLUSIONS:The clinic should strengthen the monitoring of ADR induced by antineoplastic drugs and cooperation of medical,pharmacy and patient,establish the good doctor-patient relationship,increase the medication compliance of patients,so as to reduce the incidence of ADR and promote the rational drug application in clinic.关键词
抗肿瘤药/药品不良反应/分析/监测Key words
Antineoplastic agents/Adverse drug reactions/Analysis/Monitoring分类
医药卫生
