中华临床免疫和变态反应杂志2017，Vol.11Issue(2)：106-111,6.DOI:10.3969/j.issn.1673-8705.2017.02.002
抗SmD1抗体在系统性红斑狼疮患者中的临床意义及其与临床表现的关系
Value of Anti-SmD1 Antibody in Patients with Systemic Lupus Erythematosus (SLE)and Its Relationship with Clinical Features
摘要
Abstract
Objective To study the clinical significance of anti-SmD1 antibody in the diagnosis of systemic lupus erythematosus (SLE) and its relationship with disease activity and clinical features.Methods ELISA was used to detect the anti-SmD1 antibody, anti-Sm antibody, and anti-dsDNA antibody in the sera from 150 patients with SLE and 216 patients without SLE (including 20 patients with ankylosing spondylitis(AS), 40 patients with rheumatoid arthritis(RA),33 patients with Sjogren syndrome(SS), 53 patients with systemic sclerosis(SSc) and 70 healthy subjects.The sensitivity and specificity of anti-SmD1 antibody in SLE and its relationship with disease activity and clinical features were analyzed.Results The sensitivity of anti-SmD1 antibody in 150 patients with SLE was 66.00%, which was higher than that of anti-Sm antibody (36.00%, χ2=27.01, P=0.000) and anti-dsDNA antibody (51.33%, χ2=6.65, P=0.010).The specificity of anti-SmD1 antibody, anti-Sm antibody, and anti-dsDNA antibody was 87.50%, 98.15%, and 98.61%, respectively.The presence of anti-SmD1 antibodies was significantly associated with malar rash,non-scarring alopecia(P<0.05).There was no significant association between the positivity of anti-SmD1 antibodies and other clinical characteristics of SLE such as renal disorder, arthritis, oral ulcers,serositis, hematological disorder, neurologic disorder, interstitial lung disease, and pulmonary arterial hypertension(P>0.05).The positive rate of anti-SmD1 antibody in SLE patients without anti-dsDNA antibody was 22.67%.Conclusion The anti-SmD1 antibody is more sensitive than the anti-Sm antibody and anti-dsDNA antibody for the diagnosis of SLE disease, which is of great clinical significance in the diagnosis of SLE, especially in the diagnosis of SLE with negative anti-dsDNA antibody.关键词
红斑狼疮,系统性/抗SmD1抗体/抗Sm抗体/抗ds-DNA抗体Key words
lupus erythematosus/systemic/anti-SmD1 antibody/anti-Sm antibody/anti-dsDNA antibody分类
医药卫生引用本文复制引用
王利民,胡朝军,张蜀澜,李梦涛,曾小峰..抗SmD1抗体在系统性红斑狼疮患者中的临床意义及其与临床表现的关系[J].中华临床免疫和变态反应杂志,2017,11(2):106-111,6.基金项目
国家863计划重大项目(2011AA02A104),国家自然科学基金(81373189、81302610),北京协和医学院"协和青年基金"(3332015091) （2011AA02A104）
