中华临床免疫和变态反应杂志2017，Vol.11Issue(2)：136-141,6.DOI:10.3969/j.issn.1673-8705.2017.02.007
原发性抗磷脂综合征脑卒中:19例回顾性分析
Stroke in Primary Antiphospholipid Syndrome: Retrospective Analysis of 19 Cases
苏丽 1刘倩 1朱夏媛 1朱艳辉 1赵义 1李小霞1
作者信息
- 1. 首都医科大学宣武医院风湿变态科, 北京 100053
- 折叠
摘要
Abstract
Objective To access the clinical characteristics of patients with stroke in primary antiphospholipid syndrome(APS).Methods We analyzed retrospectively 19 cases admitted at Capital Medical University Xuanwu Hospital during 2008-2016.Results The 19 patients (male∶female=11∶8) were all diagnosed of ischemic stroke.The most common vascular risk factors were hypertension, hyperlipidemia, smoking history, and atherosclerosis.Five patients (5/19) had cardiac valvular lesions with calcification.57.9% of patients were aCL(+), with 78.95% were anti-β2-GP1(+).36.8% were anti-β2-GP1 positive only.aCL+ and anti-β2-GP1+ was detected in 42.1%.Middle cerebral artery was the most frequently involved cerebral vessel (11/19), second to which was carotid artery (especially ICA).There were different levels of artery lumen stenosis(11/19), lumen occlusion(7/19), and carotid arterial intima-media thickness with plaque formation(6/19).Conclusions Patients with stroke in primary APS usually have one or more common vascular risk factors.The rate of anti-β2-GP1(+) in these patients is remarkable.It is highly recommended that patients with primary APS should be accessed routinely with transesophageal echocardiography and carotid Doppler ultrasonography to identify the risk of stroke at early stage.关键词
抗磷脂综合征/抗体,抗磷脂/血栓栓塞/脑卒中/青年脑卒中Key words
antiphospholipid syndrome/antibodies/antiphospholipid/thromboembolism/stroke/young adult stroke分类
医药卫生引用本文复制引用
苏丽,刘倩,朱夏媛,朱艳辉,赵义,李小霞..原发性抗磷脂综合征脑卒中:19例回顾性分析[J].中华临床免疫和变态反应杂志,2017,11(2):136-141,6.
