中华临床免疫和变态反应杂志2017，Vol.11Issue(2)：156-160,5.DOI:10.3969/j.issn.1673-8705.2017.02.010
抗血小板生成素及其受体抗体在系统性红斑狼疮并发血小板减少发病机制中的作用
Role of Anti-thrombopoietin and Anti-thrombopoietin Receptor Antibodyin Systemic Lupus Erythematosus-Associated Thrombocytopenia
摘要
Abstract
Thrombocytopenia is a common clinical manifestation of systemic lupus erythematosus (SLE) and is an independent risk factor for poor prognosis of SLE.Therefore, the study the pathogenesis of SLE-associated thrombocytopenia has been the focus of SLE treatment, Thrombopoietin (TPO) is the main cytokines that promotes the maturation, differentiation, and platelet release of bone marrow megakaryocytes and plays a physiological effect by binding to the specific receptor c-mpl on the target cell membrane.The role of anti-TPO antibody and anti-c-mpl antibody in the pathogenesis of SLE-associated thrombocytopenia was briefly summarized in this review.关键词
系统性红斑狼疮/血小板减少/抗血小板生成素抗体/抗c-mpl抗体Key words
systemic lupus erythematosus/thrombocytopenia/anti-thrombopoietin antibody/anti-c-mpl antibody分类
医药卫生引用本文复制引用
王维娟,李向培..抗血小板生成素及其受体抗体在系统性红斑狼疮并发血小板减少发病机制中的作用[J].中华临床免疫和变态反应杂志,2017,11(2):156-160,5.基金项目
国家自然科学基金(81373186) （81373186）
